DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment inaC and Pkn2

DIOPT Version :9

Sequence 1:NP_476863.1 Gene:inaC / 36897 FlyBaseID:FBgn0004784 Length:700 Species:Drosophila melanogaster
Sequence 2:XP_038957612.1 Gene:Pkn2 / 207122 RGDID:620146 Length:989 Species:Rattus norvegicus


Alignment Length:573 Identity:186/573 - (32%)
Similarity:274/573 - (47%) Gaps:125/573 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 RGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVF 258
            |..:.||:|.:| .|..::.            |.:|.|      :|..:.:::.|...|      
  Rat   464 RHGMCLYLEPQG-TLFAEVT------------FFNPVI------ERRPKLQRQKKIFSK------ 503

  Fly   259 NETFTFELQPQDRDKRLLIEVWDWDRTSRN-----DFMGSFSFSLEELQKEPVDGWYKFLSQVEG 318
            .:..||...||     :.|.:..|.|..|.     :..|:||      .:.||..          
  Rat   504 QQGKTFLRAPQ-----MNINIATWGRLVRRAIPTVNHSGTFS------PQTPVPA---------- 547

  Fly   319 EHYNIPCVDA-------------------------------------FNDIARLR---------- 336
               .:|.|||                                     .:|.:.||          
  Rat   548 ---TVPVVDARTPELAPPASDSTVTKLDFDLEPEAPPAPPRASSLGEIDDSSELRVLDIPGQGSE 609

  Fly   337 -----DEVRHDRRPNEKRRMDNKDMPHN--------------MSKRDMIRAADFNFVKVIGKGSF 382
                 :..|::.||..|...: .::|.:              ..:|......||....|:|:|.|
  Rat   610 TVFDIENDRNNMRPKSKSEYE-LNIPDSSRSCWSVGELEDKRSQQRFQFNLQDFRCCAVLGRGHF 673

  Fly   383 GKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILAL--SGRPPFLVSMHSCFQTMDRL 445
            |||||||.:.|:|::|:|.|:|..|:..|:::..|.||:|...  |.|.||||::.:||||.:.:
  Rat   674 GKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHV 738

  Fly   446 FFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVK 510
            .|||||..|||||.|:.. ..|.|..|:|||..|.:.|.:|||..|:||||||||:|||.||.||
  Rat   739 CFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVK 802

  Fly   511 LVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDE 575
            :.||||.|||:.....|.||||||.::|||:::...|:.|.|||..|||::|.:.|::||.||||
  Rat   803 IADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDE 867

  Fly   576 TTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEAC 640
            ..||.:|.:.:..:|:..|.||:.|:...|.:.|..|||||....:::..|||||..||......
  Rat   868 EEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTDWSALLDK 932

  Fly   641 EMEPPIKPMIKHRKDISNFDDAFTKEKTDLT-PTDKLFMMNLDQNDFIGFSFM 692
            :::||..|.|:.|:|:|||||.||.|...|| |.:...::..:|..|..|.::
  Rat   933 KVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFRDFDYV 985

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
inaCNP_476863.1 C1_1 72..124 CDD:278556
C1_1 137..189 CDD:278556
C2_PKC_alpha_gamma 194..324 CDD:175992 25/134 (19%)
S_TKc 371..629 CDD:214567 122/259 (47%)
STKc_PKC 375..692 CDD:270722 146/319 (46%)
Pkn2XP_038957612.1 HR1_PKN_1 48..113 CDD:212012
HR1_PKN2_2 134..207 CDD:212021
HR1_PKN2_3 215..288 CDD:212025
C2_PKN-like 395..478 CDD:176069 5/14 (36%)
STKc_PKN 662..987 CDD:270741 147/325 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166343100
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.840

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