Protein Alignment inaC and Pkn2

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001099225.2
• Gene: Pkn2 / 207122
• RGDID: 620146
• Length: 983
• Species: Rattus norvegicus
• Alignment Length: 573
• Identity: 186/573 - (32%)
• Similarity: 274/573 - (47%)
• Gaps: 125/573 - (21%)

  Fly   194 RGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVF 258
            |..:.||:|.:| .|..::.            |.:|.|      :|..:.:::.|...|
  Rat   458 RHGMCLYLEPQG-TLFAEVT------------FFNPVI------ERRPKLQRQKKIFSK------ 497

  Fly   259 NETFTFELQPQDRDKRLLIEVWDWDRTSRN-----DFMGSFSFSLEELQKEPVDGWYKFLSQVEG 318
            .:..||...||     :.|.:..|.|..|.     :..|:||      .:.||..
  Rat   498 QQGKTFLRAPQ-----MNINIATWGRLVRRAIPTVNHSGTFS------PQTPVPA---------- 541

  Fly   319 EHYNIPCVDA-------------------------------------FNDIARLR---------- 336
               .:|.|||                                     .:|.:.||
  Rat   542 ---TVPVVDARTPELAPPASDSTVTKLDFDLEPEAPPAPPRASSLGEIDDSSELRVLDIPGQGSE 603

  Fly   337 -----DEVRHDRRPNEKRRMDNKDMPHN--------------MSKRDMIRAADFNFVKVIGKGSF 382
                 :..|::.||..|...: .::|.:              ..:|......||....|:|:|.|
  Rat   604 TVFDIENDRNNMRPKSKSEYE-LNIPDSSRSCWSVGELEDKRSQQRFQFNLQDFRCCAVLGRGHF 667

  Fly   383 GKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILAL--SGRPPFLVSMHSCFQTMDRL 445
            |||||||.:.|:|::|:|.|:|..|:..|:::..|.||:|...  |.|.||||::.:||||.:.:
  Rat   668 GKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHV 732

  Fly   446 FFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVK 510
            .|||||..|||||.|:.. ..|.|..|:|||..|.:.|.:|||..|:||||||||:|||.||.||
  Rat   733 CFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVK 796

  Fly   511 LVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDE 575
            :.||||.|||:.....|.||||||.::|||:::...|:.|.|||..|||::|.:.|::||.||||
  Rat   797 IADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDE 861

  Fly   576 TTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEAC 640
            ..||.:|.:.:..:|:..|.||:.|:...|.:.|..|||||....:::..|||||..||......
  Rat   862 EEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTDWSALLDK 926

  Fly   641 EMEPPIKPMIKHRKDISNFDDAFTKEKTDLT-PTDKLFMMNLDQNDFIGFSFM 692
            :::||..|.|:.|:|:|||||.||.|...|| |.:...::..:|..|..|.::
  Rat   927 KVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFRDFDYV 979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342
		C1	137..190	CDD:412127
		C2_PKC_alpha_gamma	194..324	CDD:175992	25/134 (19%)
		STKc_PKC	375..692	CDD:270722	146/319 (46%)
Pkn2	NP_001099225.2	HR1_PKN_1	42..107	CDD:212012
		HR1_PKN2_2	128..201	CDD:212021
		HR1_PKN2_3	209..282	CDD:212025
		C2_PKN-like	389..472	CDD:176069	5/14 (36%)
		STKc_PKN	656..981	CDD:270741	147/325 (45%)