Protein Alignment inaC and Prkcq

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_032885.1
• Gene: Prkcq / 18761
• MGIID: 97601
• Length: 707
• Species: Mus musculus
• Alignment Length: 659
• Identity: 241/659 - (36%)
• Similarity: 345/659 - (52%)
• Gaps: 113/659 - (17%)

  Fly    57 RKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKC 121
            |:||:|:..:..|..|.|...||..||:|..|.:|:||..|||:||.:|...||:||...|:.||
Mouse   145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 209

  Fly   122 PG-----KDTDFDADCAKV--KHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQ 179
            .|     ::|.|..:..|:  .|.:....|.:||||:.||.||.|:|.||:||:.|.:||||.||
Mouse   210 TGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQ 274

  Fly   180 ETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSG--- 241
            ..|..:||.: .::..:.|..:|        ..::|.:|...:             |..|.|
Mouse   275 TKVANLCGIN-QKLMAEALAMIE--------STQQARSLRDSE-------------HIFREGPVE 317

  Fly   242 -----RTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEEL 301
                 .||.:|:       |....|      |..|:.:.:    .||
Mouse   318 IGLPCSTKNETR-------PPCVPT------PGKREPQGI----SWD------------------ 347

  Fly   302 QKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMI 366
              .|:||..|.....|.|            ::..|..::      .|.::|
Mouse   348 --SPLDGSNKSAGPPEPE------------VSMRRTSLQ------LKLKID-------------- 378

  Fly   367 RAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPF 431
               ||...|::||||||||.|||.:.|::.:|:|.|:|||::..||:|..|.||::|:|:...||
Mouse   379 ---DFILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPF 440

  Fly   432 LVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDL 496
            |..|...|||.:.|||||||..|||||||:|...:|..|.|.|||.||.:.|.|||.:.|:||||
Mouse   441 LTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEVILGLQFLHSKGIVYRDL 505

  Fly   497 KLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLF 561
            ||||||||.:||:|:.|||:.||.:.....|.||||||:|:||||:....|:.:.||||||||::
Mouse   506 KLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLVY 570

  Fly   562 EFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTH 626
            |.:.||:||.|.||..:|.:|:.....:|:....||.|::.....::|..|||    .|.:|..|
Mouse   571 EMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLG----VRGDIRQH 631

  Fly   627 PFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSF 691
            |.||.::|::.|..|::||.:|.:|...|.||||..|..||..|:..|:..:.::|||.|..|||
Mouse   632 PLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLSEKPRLSFADRALINSMDQNMFSNFSF 696

  Fly   692 MNPEFITII 700
            :||...|:|
Mouse   697 INPGMETLI 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342	24/51 (47%)
		C1	137..190	CDD:412127	26/52 (50%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	22/137 (16%)
		STKc_PKC	375..692	CDD:270722	150/316 (47%)
Prkcq	NP_032885.1	C1_nPKC_theta-like_rpt1	153..213	CDD:410384	26/59 (44%)
		C1_nPKC_theta-like_rpt2	232..281	CDD:410387	24/48 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..365		13/86 (15%)
		STKc_nPKC_theta	374..704	CDD:270770	157/350 (45%)