DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and Prkcq

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_032885.1	Gene:	Prkcq / 18761	MGIID:	97601	Length:	707	Species:	Mus musculus

Alignment Length:	659	Identity:	241/659 - (36%)
Similarity:	345/659 - (52%)	Gaps:	113/659 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKC 121
            |:||:|:..:..|..|.|...||..||:|..|.:|:||..|||:||.:|...||:||...|:.||
Mouse   145 RRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 209

  Fly   122 PG-----KDTDFDADCAKV--KHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQ 179
            .|     ::|.|..:..|:  .|.:....|.:||||:.||.||.|:|.||:||:.|.:||||.||
Mouse   210 TGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQ 274

  Fly   180 ETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSG--- 241
            ..|..:||.: .::..:.|..:|        ..::|.:|...:             |..|.|
Mouse   275 TKVANLCGIN-QKLMAEALAMIE--------STQQARSLRDSE-------------HIFREGPVE 317

  Fly   242 -----RTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEEL 301
                 .||.:|:       |....|      |..|:.:.:    .||
Mouse   318 IGLPCSTKNETR-------PPCVPT------PGKREPQGI----SWD------------------ 347

  Fly   302 QKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMI 366
              .|:||..|.....|.|            ::..|..::      .|.::|
Mouse   348 --SPLDGSNKSAGPPEPE------------VSMRRTSLQ------LKLKID-------------- 378

  Fly   367 RAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPF 431
               ||...|::||||||||.|||.:.|::.:|:|.|:|||::..||:|..|.||::|:|:...||
Mouse   379 ---DFILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPF 440

  Fly   432 LVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDL 496
            |..|...|||.:.|||||||..|||||||:|...:|..|.|.|||.||.:.|.|||.:.|:||||
Mouse   441 LTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEVILGLQFLHSKGIVYRDL 505

  Fly   497 KLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLF 561
            ||||||||.:||:|:.|||:.||.:.....|.||||||:|:||||:....|:.:.||||||||::
Mouse   506 KLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLVY 570

  Fly   562 EFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTH 626
            |.:.||:||.|.||..:|.:|:.....:|:....||.|::.....::|..|||    .|.:|..|
Mouse   571 EMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLG----VRGDIRQH 631

  Fly   627 PFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSF 691
            |.||.::|::.|..|::||.:|.:|...|.||||..|..||..|:..|:..:.::|||.|..|||
Mouse   632 PLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLSEKPRLSFADRALINSMDQNMFSNFSF 696

  Fly   692 MNPEFITII 700
            :||...|:|
Mouse   697 INPGMETLI 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	25/56 (45%)
		C1_1	137..189	CDD:278556	26/51 (51%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	22/137 (16%)
		S_TKc	371..629	CDD:214567	126/257 (49%)
		STKc_PKC	375..692	CDD:270722	150/316 (47%)
Prkcq	NP_032885.1	C1_1	160..212	CDD:278556	24/51 (47%)
		C1_1	232..284	CDD:278556	26/51 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..365		13/86 (15%)
		STKc_nPKC_theta	374..704	CDD:270770	157/350 (45%)
		S_TKc	380..634	CDD:214567	126/257 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910