back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and Prkci

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_032883.2	Gene:	Prkci / 18759	MGIID:	99260	Length:	595	Species:	Mus musculus

Alignment Length:	689	Identity:	219/689 - (31%)
Similarity:	306/689 - (44%)	Gaps:	219/689 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFK 80
            |.||. .||...|               ||.      |:..|:||.:.:.|...|||.|..:.|.
Mouse   107 PCVPE-RPGMPCP---------------GED------KSIYRRGARRWRKLYCANGHTFQAKRFN 149

  Fly    81 NPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYT 145
            ...:|..|.|.|||.|:||::|..|:..:|:||.|.|..
Mouse   150 RRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTI-------------------------- 188

  Fly   146 TPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKV 210
                  |||                        :.::||
Mouse   189 ------ECG------------------------RHSLPP-------------------------- 197

  Fly   211 DIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRL 275
                 ..::|||..          ||||.       |:|:.. .||..:|:
Mouse   198 -----EPMMPMDQT----------MHPDH-------TQTVIP-YNPSSHES-------------- 225

  Fly   276 LIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVR 340
                                                 |.|| ||
Mouse   226 -------------------------------------LDQV-GE--------------------- 231

  Fly   341 HDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKD 405
                  ||..|:.::.....|.   :...||:.::|||:||:.||||...:.||.:||:||::|:
Mouse   232 ------EKEAMNTRESGKASSS---LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKE 287

  Fly   406 VIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKES 470
            ::...:|::....||.:...:...||||.:||||||..|||||:||..|||||:|||:..:..|.
Mouse   288 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE 352

  Fly   471 VAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPN 535
            .|.||:.|:::||.:||||.||||||||||:|||.|||:||.|:|:.|||:....||.|||||||
Mouse   353 HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPN 417

  Fly   536 YMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPF------EGDDETT---VFRNIKDKKAVFPK 591
            |:||||:..:.|..:.|||:.|||:||.|||::||      :..|:.|   :|:.|.:|:...|:
Mouse   418 YIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 482

  Fly   592 HFSVEAMDIITSFLTKKPNNRLGA-GRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKD 655
            ..||:|..::.|||.|.|..|||. .:....:|..||||||||||..|..::.||.||.|.....
Mouse   483 SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFG 547

  Fly   656 ISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNP 694
            :.|||..||.|...|||.|...:..:||::|.||.::||
Mouse   548 LDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 586

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.