Protein Alignment inaC and Prkcd

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001297611.1
• Gene: Prkcd / 18753
• MGIID: 97598
• Length: 700
• Species: Mus musculus
• Alignment Length: 654
• Identity: 240/654 - (36%)
• Similarity: 341/654 - (52%)
• Gaps: 117/654 - (17%)

  Fly    57 RKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKC 121
            |:||:|:..:..:..|.|...||..||:|..||:|:||..|||::|.:|...||:||...::.:|
Mouse   144 RRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 208

  Fly   122 PG-----KDTDFDADCAKV--KHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQ 179
            .|     :||.|..:...:  .|.:....|.:|||||.||.||.|:..||:|||:|.:||||.|:
Mouse   209 TGTATNSRDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCR 273

  Fly   180 ETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTK 244
            |.|..:||     :..|||              .||.|.:                 ..||.|..
Mouse   274 EKVANLCG-----INQKLL--------------AEALNQV-----------------TQRSSRKL 302

  Fly   245 KKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGW 309
            ..|:::     .::.   .||.:|:               .|.:|.:|.
Mouse   303 DTTESV-----GIYQ---GFEKKPE---------------VSGSDILGE---------------- 328

  Fly   310 YKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMI-------R 367
                   .|.|.::..  :|               |:..:..|:.:...|......|       .
Mouse   329 -------AGSHISLKL--SF---------------PSRAKEKDSSETCDNNGTYGKIWEGSTRCT 369

  Fly   368 AADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFL 432
            ..:|.|.||:||||||||||||.:|.|:.:|:|.|:|||::..||:|..|.||::|||:...|||
Mouse   370 LENFTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFL 434

  Fly   433 VSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLK 497
            ..:...|||.|.||||||:..|||||:|:|..|||:...|.|||.|:...|.|||.:.|||||||
Mouse   435 THLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLK 499

  Fly   498 LDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFE 562
            |||::||.:||:|:.|||:.||.:.......||||||:|:||||:....||.:.|||||||||:|
Mouse   500 LDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYE 564

  Fly   563 FMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHP 627
            .:.||:||.||||..:|.:|:.....:|:..:.|:.||:.....:.|:.|||    ....|..||
Mouse   565 MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLG----VTGNIRIHP 625

  Fly   628 FFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFM 692
            ||:.::|...|..::|||.||.:|...|.||||..|..||..|:.:||..:.::||..|.||||:
Mouse   626 FFKTINWSLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAFHGFSFV 690

  Fly   693 NPEF 696
            ||:|
Mouse   691 NPKF 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342	22/51 (43%)
		C1	137..190	CDD:412127	27/52 (52%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	18/129 (14%)
		STKc_PKC	375..692	CDD:270722	154/316 (49%)
Prkcd	NP_001297611.1	C1_nPKC_theta-like_rpt1	152..212	CDD:410384	23/59 (39%)
		C1_nPKC_theta-like_rpt2	231..280	CDD:410387	25/48 (52%)
		Protein Kinases, catalytic domain	377..692	CDD:473864	155/318 (49%)