DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and Prkcb

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_032881.1	Gene:	Prkcb / 18751	MGIID:	97596	Length:	673	Species:	Mus musculus

Alignment Length:	682	Identity:	349/682 - (51%)
Similarity:	465/682 - (68%)	Gaps:	30/682 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFI 92
            ||||....       .||.:.|.:    .||||:::|.:..|..|:|..||||.||:|.||.|||
Mouse     4 PAAGPPPS-------EGEESTVRF----ARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFI 57

  Fly    93 WGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLL 157
            ||||||||||:.|.|.:|::|.:||.|.|||.|....:|..:.||.:...||::|||||.||.||
Mouse    58 WGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLL 122

  Fly   158 HGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMD 222
            :|:.|||:||:.|.:|||..|...||.:||.|.:|.||::.:...:....|.|.:::|.||:|||
Mouse   123 YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMD 187

  Fly   223 TNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSR 287
            .||.||||:.:::.||....:|:|||||:.:|||.:||||.|:|:..|:|:||.:|:||||.|||
Mouse   188 PNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSR 252

  Fly   288 NDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPC-VDAFNDIARLRDEVRH------DRRP 345
            ||||||.||.:.||||..||||:|.|||.|||::|:|. .:.......||.:...      .:.|
Mouse   253 NDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAP 317

  Fly   346 NEK-----RRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKD 405
            .||     .:.||.      ..||.::..||||:.|:||||||||:|:||:|||||||||:|:||
Mouse   318 EEKTANTISKFDNN------GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 376

  Fly   406 VIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKES 470
            |:||.||:|..|.||::|||.|:||||..:||||||||||:|||||..|||||||:||.|||||.
Mouse   377 VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP 441

  Fly   471 VAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPN 535
            .|:|||.|:||.||||..:.||||||||||::||.|||:|:.|||:.||.:.:..||:||||||:
Mouse   442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD 506

  Fly   536 YMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDI 600
            |:||||::|.||..:.|||:|||||:|.:||||||||:||..:|::|.:....:||..|.||:.|
Mouse   507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571

  Fly   601 ITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTK 665
            ....:||.|..|||.|....::|..|.|||.:||:|.|..|::||.||....| :..|||..||:
Mouse   572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFTR 635

  Fly   666 EKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFI 697
            ....|||.|:..:.|:||::|.||||:|.||:
Mouse   636 HPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFL 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	33/51 (65%)
		C1_1	137..189	CDD:278556	27/51 (53%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	69/129 (53%)
		S_TKc	371..629	CDD:214567	157/257 (61%)
		STKc_PKC	375..692	CDD:270722	183/316 (58%)
Prkcb	NP_032881.1	C1_cPKC_rpt1	35..92	CDD:410383	35/56 (63%)
		C1_cPKC_rpt2	102..155	CDD:410386	27/52 (52%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	69/129 (53%)
		STKc_cPKC_beta	341..663	CDD:270767	188/322 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839297
Domainoid	1	1.000	63	1.000	Domainoid score	I10199
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103255
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.710