DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and Prkca

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_036012317.1	Gene:	Prkca / 18750	MGIID:	97595	Length:	688	Species:	Mus musculus

Alignment Length:	687	Identity:	341/687 - (49%)
Similarity:	469/687 - (68%)	Gaps:	37/687 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGF 100
            |.|  :.|...::.|..   .||||:::|.:..|..|:|..||||.||:|.||.|||||||||||
Mouse     6 PAN--DSTASQDVANRF---ARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGF 65

  Fly   101 QCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLHGVAHQGV 165
            ||:.|.|.:|::|.:||.|.|||.|...|.|..:.||.:...||.:|||||.||.||:|:.|||:
Mouse    66 QCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGM 130

  Fly   166 KCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPY 230
            ||:.|::|||..|...||.:||.|.:|.||::.|..|:....|.|.:::|.||||||.||.||||
Mouse   131 KCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPY 195

  Fly   231 IAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFS 295
            :.:::.||....:|:|||||:..|||.:||:|||:|:|.|:|:||.:|:||||||:|||||||.|
Mouse   196 VKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLS 260

  Fly   296 FSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFND-IARLRDEVRHDR---------RPNEKRR 350
            |.:.||.|.|..||||.|:|.|||:||:|..:...: ...||.:....:         .|:|.|:
Mouse   261 FGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRK 325

  Fly   351 MDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMEL 415
            ..:.::       |.::..||||:.|:||||||||:||:|:||:||||:|:|:|||:||.||:|.
Mouse   326 QPSNNL-------DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVEC 383

  Fly   416 PMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVA 480
            .|.||::|||..:||||..:||||||:|||:|||||..|||||||:||.|:|||..|:|||.|::
Mouse   384 TMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEIS 448

  Fly   481 IALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYD 545
            |.|||||:|.||||||||||::||.|||:|:.|||:.||.:.:..|||||||||:|:||||::|.
Mouse   449 IGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQ 513

  Fly   546 PYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPN 610
            ||..:.|||::||||:|.:|||.||:|:||..:|::|.:....:||..|.||:.|....:||.|.
Mouse   514 PYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA 578

  Fly   611 NRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKH---------------RKDISNFD 660
            .|||.|....:::..|.|||.:||:|.|..|::||.||.:..               .|...|||
Mouse   579 KRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVTFCTKMHWLQWASRPSCGKGAENFD 643

  Fly   661 DAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFI 697
            ..||:.:..|||.|:|.:.|:||:||.|||::||:|:
Mouse   644 KFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFV 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	33/51 (65%)
		C1_1	137..189	CDD:278556	27/51 (53%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	72/129 (56%)
		S_TKc	371..629	CDD:214567	150/257 (58%)
		STKc_PKC	375..692	CDD:270722	178/331 (54%)
Prkca	XP_036012317.1	C1_cPKC_rpt1	35..92	CDD:410383	35/56 (63%)
		C1_cPKC_rpt2	102..155	CDD:410386	27/52 (52%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	72/129 (56%)
		STKc_cPKC_alpha	328..684	CDD:270766	186/360 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0696
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103255
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.710