Protein Alignment inaC and pkc-1

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001256396.1
• Gene: pkc-1 / 179649
• WormBaseID: WBGene00004032
• Length: 763
• Species: Caenorhabditis elegans
• Alignment Length: 662
• Identity: 262/662 - (39%)
• Similarity: 362/662 - (54%)
• Gaps: 121/662 - (18%)

  Fly    50 NYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCC 114
            |...:|.|:|||:|| :..|.||:|...|.:.||:|.|||:||||.||||:||:.|...:|::|.
 Worm   206 NAFNDRQRRGAMRRK-IHEVTGHKFMALFLRQPTFCAHCKEFIWGIGKQGYQCQICTVVVHKRCH 269

  Fly   115 KFVVFKCPGKDTDFDADCAK-------------VKHGWISTTYTTPTFCDECGLLLHGVAHQGVK 166
            :.||:||||...|...:..|             :.|.:...:|..|||||.||.:|:|:.:||::
 Worm   270 EDVVWKCPGNKADAVEELGKEIQETGAGRFNINMPHRFSVHSYKRPTFCDHCGSMLYGLINQGLQ 334

  Fly   167 CENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYI 231
            |..|.||||..||..|...||.:..::..: |..:.|.|:.:.:
 Worm   335 CSTCKLNVHKRCQRNVANNCGINAKQMAAE-LAQLGLTGDKMSI--------------------- 377

  Fly   232 AVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSF 296
                      |:|||..        :..:|.|                         |..||
 Worm   378 ----------RSKKKPS--------IMTDTST-------------------------DISGS--- 396

  Fly   297 SLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMS 361
                             |..|...|              ..::..|.......|..:|.....:|
 Worm   397 -----------------SNSENSGY--------------LQQISEDDSGTTSSRSASKVPGGTLS 430

  Fly   362 KRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALS 426
                  ..||.|:||:||||||||:||||:||||:||:|:|:||||:|.||:|..|.||:||:|:
 Worm   431 ------IHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLA 489

  Fly   427 GRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDI 491
            .:.|||.::||.|||.|||||||||..|||||:.:|:..:|.||.|.|||.||..||.|||..|:
 Worm   490 AKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDV 554

  Fly   492 IYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSF 556
            |||||||||||||.|||.:|.|||:.|||:.:...|.||||||:|:||||:....|.::.|||:.
 Worm   555 IYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWAL 619

  Fly   557 GVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLG--AGRYA 619
            |||::|.||||.|||.|:|..:|..|.:...::|...|.||::|:.:|:||....|||  ..:..
 Worm   620 GVLMYEMMAGQPPFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGG 684

  Fly   620 RQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQN 684
            ...|..|||||.:|||..|:.:::||.||.||.::|.:|||..||||:..|||:|...:..::|:
 Worm   685 EDAIRAHPFFREIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAVVRAINQD 749

  Fly   685 DFIGFSFMNPEF 696
            :|.||||:||.|
 Worm   750 EFRGFSFINPHF 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342	27/51 (53%)
		C1	137..190	CDD:412127	24/52 (46%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	15/129 (12%)
		STKc_PKC	375..692	CDD:270722	172/318 (54%)
pkc-1	NP_001256396.1	C2_PKC_epsilon	59..188	CDD:175981
		C1_nPKC_epsilon-like_rpt1	218..280	CDD:410385	32/62 (52%)
		C1_nPKC_epsilon-like_rpt2	303..357	CDD:410388	24/53 (45%)
		STKc_nPKC_epsilon	438..758	CDD:270743	173/319 (54%)