DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and pkc-1

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001256396.1	Gene:	pkc-1 / 179649	WormBaseID:	WBGene00004032	Length:	763	Species:	Caenorhabditis elegans

Alignment Length:	662	Identity:	262/662 - (39%)
Similarity:	362/662 - (54%)	Gaps:	121/662 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 NYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCC 114
            |...:|.|:|||:|| :..|.||:|...|.:.||:|.|||:||||.||||:||:.|...:|::|.
Worm   206 NAFNDRQRRGAMRRK-IHEVTGHKFMALFLRQPTFCAHCKEFIWGIGKQGYQCQICTVVVHKRCH 269

  Fly   115 KFVVFKCPGKDTDFDADCAK-------------VKHGWISTTYTTPTFCDECGLLLHGVAHQGVK 166
            :.||:||||...|...:..|             :.|.:...:|..|||||.||.:|:|:.:||::
Worm   270 EDVVWKCPGNKADAVEELGKEIQETGAGRFNINMPHRFSVHSYKRPTFCDHCGSMLYGLINQGLQ 334

  Fly   167 CENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYI 231
            |..|.||||..||..|...||.:..::..: |..:.|.|:.:.:
Worm   335 CSTCKLNVHKRCQRNVANNCGINAKQMAAE-LAQLGLTGDKMSI--------------------- 377

  Fly   232 AVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSF 296
                      |:|||..        :..:|.|                         |..||
Worm   378 ----------RSKKKPS--------IMTDTST-------------------------DISGS--- 396

  Fly   297 SLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMS 361
                             |..|...|              ..::..|.......|..:|.....:|
Worm   397 -----------------SNSENSGY--------------LQQISEDDSGTTSSRSASKVPGGTLS 430

  Fly   362 KRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALS 426
                  ..||.|:||:||||||||:||||:||||:||:|:|:||||:|.||:|..|.||:||:|:
Worm   431 ------IHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLA 489

  Fly   427 GRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDI 491
            .:.|||.::||.|||.|||||||||..|||||:.:|:..:|.||.|.|||.||..||.|||..|:
Worm   490 AKHPFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARFYAAEVTCALQFLHRNDV 554

  Fly   492 IYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSF 556
            |||||||||||||.|||.:|.|||:.|||:.:...|.||||||:|:||||:....|.::.|||:.
Worm   555 IYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWAL 619

  Fly   557 GVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLG--AGRYA 619
            |||::|.||||.|||.|:|..:|..|.:...::|...|.||::|:.:|:||....|||  ..:..
Worm   620 GVLMYEMMAGQPPFEADNEDDLFEAILNDDVLYPVWLSKEAVNILKAFMTKNAGKRLGCVVSQGG 684

  Fly   620 RQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQN 684
            ...|..|||||.:|||..|:.:::||.||.||.::|.:|||..||||:..|||:|...:..::|:
Worm   685 EDAIRAHPFFREIDWDALESRQVKPPFKPKIKSKRDANNFDSDFTKEEPVLTPSDPAVVRAINQD 749

  Fly   685 DFIGFSFMNPEF 696
            :|.||||:||.|
Worm   750 EFRGFSFINPHF 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	27/51 (53%)
		C1_1	137..189	CDD:278556	24/51 (47%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	15/129 (12%)
		S_TKc	371..629	CDD:214567	144/259 (56%)
		STKc_PKC	375..692	CDD:270722	172/318 (54%)
pkc-1	NP_001256396.1	C2_PKC_epsilon	59..188	CDD:175981
		C1_1	227..279	CDD:278556	27/51 (53%)
		C1_1	305..357	CDD:278556	24/51 (47%)
		S_TKc	434..694	CDD:214567	144/259 (56%)
		STKc_nPKC_epsilon	438..758	CDD:270743	173/319 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910