Protein Alignment inaC and aPKC

DIOPT Version :10

• Sequence 1: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_061518621.1
• Gene: aPKC / 1280683
• VectorBaseID: AGAMI1_009490
• Length: 826
• Species: Anopheles gambiae
• Alignment Length: 702
• Identity: 220/702 - (31%)
• Similarity: 315/702 - (44%)
• Gaps: 216/702 - (30%)

  Fly    11 ATVLPPSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFG 75
            |||. |:||||              ||  |...||...:      .|:||.:.:.|..:|||.|.
Mosquito   324 ATVF-PNVPSA--------------PG--LSCVGEDRSI------YRRGARRWRKLYRINGHIFQ 365

  Fly    76 VRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWI 140
            .:.|....:|..|.|.|||.|:|||:|.:|:..:|:||.|.
Mosquito   366 AKRFNRKAFCAFCHDRIWGLGRQGFKCIQCKLLVHKKCHKL------------------------ 406

  Fly   141 STTYTTPTFCDECGLLLHGVAHQGVK-CENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELK 204
                                   |.| |.|          |.|.|:
Mosquito   407 -----------------------GNKPCSN----------EHVEPV------------------- 419

  Fly   205 GNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQ 269
                   .||..:..|.|.:...|                    .||..|:      :..||...
Mosquito   420 -------FKERDHHDPNDESSTGD--------------------VIQAPLD------YPSELHSG 451

  Fly   270 DRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIAR 334
            |...::.:||        ||       ::||.           |..|....|::
Mosquito   452 DGCDQVPVEV--------ND-------NVEET-----------LEPVTQRQYSL----------- 479

  Fly   335 LRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAV 399
                                              .||..::|||:||:.|||:.|.:.|..:||:
Mosquito   480 ----------------------------------NDFELIRVIGRGSYAKVLMVELKKTRRIYAM 510

  Fly   400 KVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQY 464
            ||::|.::...:|::....||.:...:...||||.:||||||..|||||:|:.:|||||:|||:.
Mosquito   511 KVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMFHMQRQ 575

  Fly   465 GRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRT 529
            .|..|..|.|||.|:::||.||||:.||||||||||:|||.|||:||.|:|:.|||:....||.|
Mosquito   576 RRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTST 640

  Fly   530 FCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPF------EGDDETT---VFRNIKDK 585
            |||||||:||||:..:.|..:.|||:.||||:|.:||::||      |..|:.|   :|:.|.:|
Mosquito   641 FCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDIAGASENPDQNTEDYLFQVILEK 705

  Fly   586 KAVFPKHFSVEAMDIITSFLTKKPNNRLGAGR-YARQEITTHPFFRNVDWDKAEACEMEPPIKPM 649
            ....|:..||:|..::..||.|.|.:|||..| .|..:|..|.||:::||:.....|:.||..|.
Mosquito   706 TIRIPRSLSVKAASVLKGFLNKNPADRLGCNRDSAFLDIMNHSFFKSIDWEMLAQKEVTPPYIPS 770

  Fly   650 IKH-RKDIS-NFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFITI 699
            ... .:||: :||..||:|..||||.|...:..:||::|.||.::||..:::
Mosquito   771 FDGCDQDITCHFDPQFTREPADLTPDDPRVIDKIDQSEFEGFEYVNPLLMSL 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342	20/51 (39%)
		C1	137..190	CDD:412127	7/53 (13%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	20/129 (16%)
		STKc_PKC	375..692	CDD:270722	151/328 (46%)
aPKC	XP_061518621.1	None