back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and prkci

DIOPT Version :10

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_571930.2	Gene:	prkci / 117507	ZFINID:	ZDB-GENE-011105-1	Length:	588	Species:	Danio rerio

Alignment Length:	689	Identity:	209/689 - (30%)
Similarity:	296/689 - (42%)	Gaps:	219/689 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PSVPSAAPGAKAPAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFK 80
            |.||. .||...|               ||.      |:..|:||.:.:.|....||.|..:.|.
Zfish   100 PCVPE-KPGMPCP---------------GED------KSIYRRGARRWRKLYYATGHAFQAKRFN 142

  Fly    81 NPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYT 145
            ...:|..|.|.|||.|:||::|..|:..:|:||.|.|..:| |:....|
Zfish   143 RRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTVEC-GRQVIQD---------------- 190

  Fly   146 TPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKV 210
                                                  ||.|.
Zfish   191 --------------------------------------PMIGR---------------------- 195

  Fly   211 DIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRL 275
                            .||......|||:....|..|::|..
Zfish   196 ----------------IDPGSTHPEHPDQVLGKKNSTESINH----------------------- 221

  Fly   276 LIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVR 340
                                                     |||
Zfish   222 -----------------------------------------EGE--------------------- 224

  Fly   341 HDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKD 405
                  |...:.:::....:|...:|   ||:.::|||:||:.||||...:.|:.:||:||::|:
Zfish   225 ------EHEAVGSRESGKAVSSLGLI---DFDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKE 280

  Fly   406 VIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKES 470
            ::...:|::....||.:...:...||||.:||||||..|||||:||..|||||:|||:..:..|.
Zfish   281 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE 345

  Fly   471 VAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPN 535
            .|.||:.|:::||.:||||.||||||||||:|||.|||:||.|:|:.|||:....||.|||||||
Zfish   346 HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPN 410

  Fly   536 YMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPF------EGDDETT---VFRNIKDKKAVFPK 591
            |:||||:..:.|..:.|||:.|||:||.|||::||      :..|:.|   :|:.|.:|:...|:
Zfish   411 YIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 475

  Fly   592 HFSVEAMDIITSFLTKKPNNRLGA-GRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKD 655
            ..||:|..::..||.|:...|||. .:....:|..||||||||||..|..::.||.||.|.....
Zfish   476 SLSVKAASVLKGFLNKESKERLGCHPQTGFADIMAHPFFRNVDWDLMEQKQVVPPFKPNISGEFG 540

  Fly   656 ISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNP 694
            :.|||..||.|...|||.|...:..:||::|.||.::||
Zfish   541 LDNFDAQFTNEPIQLTPDDDDAVKKIDQSEFEGFEYINP 579

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.