DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and Pkn2

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_848769.2	Gene:	Pkn2 / 109333	MGIID:	109211	Length:	983	Species:	Mus musculus

Alignment Length:	576	Identity:	189/576 - (32%)
Similarity:	274/576 - (47%)	Gaps:	131/576 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 RGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVF 258
            |..:.||:|.:| .|..::.            |.:|.|      :|..:.:::.|...|
Mouse   458 RHGMCLYLEPQG-TLFAEVT------------FFNPVI------ERRPKLQRQKKIFSK------ 497

  Fly   259 NETFTFELQPQDRDKRLLIEVWDWDRTSRN-----DFMGSFSFSLEELQKEPVDGWYKFLSQVEG 318
            .:..||...||     :.|.:..|.|..|.     :..|:||      .:.||..
Mouse   498 QQGKTFLRAPQ-----MNINIATWGRLVRRAIPTVNHSGTFS------PQTPVPA---------- 541

  Fly   319 EHYNIPCVDA-FNDIA--------------------------------------RLRD------- 337
               .:|.||| ..|:|                                      |:.|
Mouse   542 ---TVPVVDARIPDLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGETDESSELRVLDIPGQGSE 603

  Fly   338 ---EVRHDR---RPNEKR-----------------RMDNKDMPHNMSKRDMIRAADFNFVKVIGK 379
               .:.:||   ||..|.                 .:|:|    ...:|......||....|:|:
Mouse   604 TVFNIENDRNNLRPKSKSEYELSIPDSGRSCWGVGELDDK----RAQQRFQFSLQDFRCCAVLGR 664

  Fly   380 GSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILAL--SGRPPFLVSMHSCFQTM 442
            |.||||||||.:.|:|::|:|.|:|..|:..|:::..|.||:|...  |.|.||||::.:||||.
Mouse   665 GHFGKVLLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTK 729

  Fly   443 DRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEG 507
            :.:.|||||..|||||.|:.. ..|.|..|:|||..|.:.|.:|||..|:||||||||:|||.||
Mouse   730 EHVCFVMEYAAGGDLMMHIHT-DVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEG 793

  Fly   508 HVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEG 572
            .||:.||||.|||:.....|.||||||.::|||:::...|:.|.|||..|||::|.:.|::||.|
Mouse   794 FVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPG 858

  Fly   573 DDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKA 637
            |||..||.:|.:.:..:|:..|.||:.|:...|.:.|..|||||....:::..|||||..||...
Mouse   859 DDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTDWSAL 923

  Fly   638 EACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLT-PTDKLFMMNLDQNDFIGFSFM 692
            ...:::||..|.|:.|:|:|||||.||.|...|| |.:...::..:|..|..|.::
Mouse   924 MDKKVKPPFVPTIRGREDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFHDFDYV 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992	25/134 (19%)
		S_TKc	371..629	CDD:214567	122/259 (47%)
		STKc_PKC	375..692	CDD:270722	146/319 (46%)
Pkn2	NP_848769.2	HR1_PKN_1	42..107	CDD:212012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	107..135
		HR1_PKN2_2	128..201	CDD:212021
		HR1_PKN2_3	209..282	CDD:212025
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..382
		Necessary to rescue apical junction formation	381..462		1/3 (33%)
		C2_PKN-like	389..472	CDD:176069	5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..588		1/34 (3%)
		STKc_PKN	656..981	CDD:270741	147/325 (45%)
		S_TKc	661..915	CDD:214567	121/254 (48%)
		Necessary for the catalytic activity. /evidence=ECO:0000250	916..976		22/59 (37%)
		Negatively regulates the responsiveness of the catalytic activity by cardiolipin and is required for optimal activation by the GTP-bound RhoA. /evidence=ECO:0000250	977..983		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840