DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and sgk3

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_012820716.1	Gene:	sgk3 / 100491891	XenbaseID:	XB-GENE-492582	Length:	490	Species:	Xenopus tropicalis

Alignment Length:	433	Identity:	158/433 - (36%)
Similarity:	231/433 - (53%)	Gaps:	28/433 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 KRLLIEVWDWD-----RTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDI 332
            ||:..:.:|.|     |...|:|:.:.....|......|.   .||.....:|.:.|..|
Frog    69 KRIFGDNFDPDFIQQRRAGLNEFIQNLLRHSELCSHSDVQ---SFLQLDSPKHQSDPSED----- 125

  Fly   333 ARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELY 397
                    .|.|.::|....::|:....|.....:.:||.::|:|||||||||:|...:.....|
Frog   126 --------EDERVDQKNGSASRDVNLGPSGNPHAKPSDFEYLKLIGKGSFGKVVLTRGKRDGRYY 182

  Fly   398 AVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQ 462
            |||||:|:||:...:....|.|:.:|..:.:.||||::|..|||.|:||||:::..||:|.:|:|
Frog   183 AVKVLQKNVILNKKEQRHIMAERNVLLKNVKHPFLVTLHYSFQTSDKLFFVLDFINGGELFFHLQ 247

  Fly   463 QYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTT 527
            :...|.|..|:|||.|:..||.:||..||||||||.:|||||.:||:.|.||||.|||::...||
Frog   248 RERYFAEPRALFYAAEIGSALGYLHSIDIIYRDLKPENILLDSQGHIVLTDFGLCKEGISNSDTT 312

  Fly   528 RTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKH 592
            .||||||.|:|||::...||....|||..|.:|:|.:.|..||...|..|::.||..|.......
Frog   313 LTFCGTPEYLAPEVIVKQPYDNTVDWWCLGSVLYEMLHGLPPFYNRDTATMYENILHKPLTTRPD 377

  Fly   593 FSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDIS 657
            .|:.|:.|:...|.|.|..|||... ..|:|..|.||.:::|......:|.||..|.:....|||
Frog   378 ISLPAISILEELLEKDPKLRLGVNN-DFQDIKNHAFFASINWADLVEKKMTPPYDPHVNGPDDIS 441

  Fly   658 NFDDAFTKEKTD----LTPTDKLFMMNLDQND--FIGFSFMNP 694
            |||..||:|...    ::....:...::::.|  |:|||:..|
Frog   442 NFDKEFTEEMVPYSVCVSSDYSIVNASVEEADDAFVGFSYAPP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992	12/55 (22%)
		S_TKc	371..629	CDD:214567	116/257 (45%)
		STKc_PKC	375..692	CDD:270722	136/322 (42%)
sgk3	XP_012820716.1	PX_domain	7..114	CDD:383026	11/47 (23%)
sgk3	XP_012820716.1	STKc_SGK3	159..484	CDD:270755	136/325 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920