DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and akt1

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_004917247.1	Gene:	akt1 / 100490038	XenbaseID:	XB-GENE-484953	Length:	493	Species:	Xenopus tropicalis

Alignment Length:	472	Identity:	155/472 - (32%)
Similarity:	243/472 - (51%)	Gaps:	47/472 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 KKKTKTIQKNLNPVFN-ETFTFELQPQDRDK--RLLIEVWDW----DRTSRNDFMGSFSFSLEEL 301
            |::.:.:.:...|:.| .....:|...:|.|  ..:|....|    :||...|       |.||.
Frog    39 KERPQDVDQLETPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVD-------SPEER 96

  Fly   302 QKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMI 366
            ::     |.:.:..|         .|..........|||....|::....:..::.|:..|. .:
Frog    97 EE-----WIQVIQHV---------ADNLKKQEEEMMEVRSGDSPSDNSGAEEMEVSHSKPKH-KV 146

  Fly   367 RAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPF 431
            ...:|.::|::|||:||||:|.:.:.|...||:|:|:|:||:..|::...:.|.::|. :.|.||
Frog   147 TMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRHPF 210

  Fly   432 LVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLH-ERDIIYRD 495
            |.::...|||.|||.|||||..||:|.:|:.:...|.|..|.||..|:..||.:|| |::::|||
Frog   211 LTALKYSFQTHDRLCFVMEYANGGELFFHLSRERIFSEDRARFYGAEIVSALDYLHSEKNVVYRD 275

  Fly   496 LKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLL 560
            |||:|::||.:||:|:.||||.|||:.:..|.:||||||.|:|||::..:.|..|.|||..||::
Frog   276 LKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVM 340

  Fly   561 FEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITT 625
            :|.|.|:.||...|...:|..|..::..||:....||..:::..|.|.|..|||.|....:||..
Frog   341 YEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLLPEAKSLLSGLLKKDPKQRLGGGPDDAKEIMQ 405

  Fly   626 HPFFRNVDWD------------KAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDK--- 675
            |.||..:.|.            |....|:.||.||.:....|...||:.||.:...:||.|:
Frog   406 HKFFAGIVWQDVYEKKMLSVVTKQSKVELIPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDN 470

  Fly   676 -LFMMNLDQNDFIGFSF 691
             .|:.|..:..|..||:
Frog   471 LEFVDNERRPHFPQFSY 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992	16/86 (19%)
		S_TKc	371..629	CDD:214567	110/258 (43%)
		STKc_PKC	375..692	CDD:270722	131/334 (39%)
akt1	XP_004917247.1	PH_PKB	4..111	CDD:269947	17/92 (18%)
akt1	XP_004917247.1	PKc_like	125..491	CDD:419665	135/365 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010