DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and prkch

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_002939521.2	Gene:	prkch / 100151731	XenbaseID:	XB-GENE-486685	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	659	Identity:	248/659 - (37%)
Similarity:	342/659 - (51%)	Gaps:	154/659 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 RLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWG-FGKQGFQCEECRFNIHQKCCKFVV 118
            |.|:.||:|: :..||||:|...:.|.||||.|||||||| |||||:||:.|...:|::|.:.:|
Frog   155 RKRQRAMRRR-VHQVNGHKFMATYLKQPTYCSHCKDFIWGVFGKQGYQCQVCTCVVHKRCHQLIV 218

  Fly   119 FKCPGKDTDFDADCAKVK-------------HGWISTTYTTPTFCDECGLLLHGVAHQGVKCENC 170
            ..|..|.|     .:||:             |.:....|..|||||.||.||.|:..||::|:.|
Frog   219 TACTCKST-----TSKVEKQIFEQRFGINLPHKFRYHNYKVPTFCDHCGSLLWGLVKQGLQCKIC 278

  Fly   171 NLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQM 235
            .:|||..|:..|...||.:                   .||:..|              ...:.:
Frog   279 KMNVHKRCEANVAHNCGVN-------------------SVDLANA--------------LAGMGL 310

  Fly   236 HPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEE 300
            ||   |....|..::..:::                                     |.|..|||
Frog   311 HP---GNIPFKQHSVSGSVD-------------------------------------SDSNHLEE 335

  Fly   301 LQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDM 365
            .........|||            .:|
Frog   336 DSISNTSSQYKF------------GID-------------------------------------- 350

  Fly   366 IRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPP 430
                ||.|::|:||||||||:||:.:.:|.|||||||:||||:|.||:|..|.||:||:|:...|
Frog   351 ----DFTFLRVLGKGSFGKVMLAKSKESDSLYAVKVLKKDVILQDDDVECTMTEKRILSLACNHP 411

  Fly   431 FLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRD 495
            ||..:..||||:||||||||:..|||||:|:|:..||.|:.|.||:.|:..||.|||::.:||||
Frog   412 FLTQLFCCFQTLDRLFFVMEFVNGGDLMFHIQKSRRFDEARACFYSAEITSALMFLHDKGVIYRD 476

  Fly   496 LKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLL 560
            |||||:|||.|||.||.|||:.|||:.|..||.||||||:|:||||:....|....|||:.||||
Frog   477 LKLDNVLLDHEGHCKLADFGMCKEGIREGCTTSTFCGTPDYIAPEILQEMQYGPLVDWWAMGVLL 541

  Fly   561 FEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGA----GRYARQ 621
            :|.:.|.||||.::|..:|..|.:.:.|:|...|.:|::|:.:|:.|||..|||:    |..|
Frog   542 YEMLCGHAPFEAENEDDLFEAILNDEVVYPGWLSQDAVEILQAFMKKKPAKRLGSLSLGGEKA-- 604

  Fly   622 EITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDF 686
             |..||||::::||:.....:|||.:|.||.|:|:||||..|.||...|||.|:..:..::|.:|
Frog   605 -ILWHPFFKDINWDELNKKTIEPPFRPRIKAREDVSNFDPEFIKEDAVLTPIDESLLPLINQEEF 668

  Fly   687 IGFSFMNPE 695
            ..||:..||
Frog   669 RNFSYTAPE 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	27/52 (52%)
		C1_1	137..189	CDD:278556	23/51 (45%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	15/129 (12%)
		S_TKc	371..629	CDD:214567	140/261 (54%)
		STKc_PKC	375..692	CDD:270722	165/320 (52%)
prkch	XP_002939521.2	C2_PKC_epsilon	7..139	CDD:175981
		C1_1	171..221	CDD:365894	26/49 (53%)
		C1_1	245..295	CDD:365894	21/49 (43%)
		STKc_nPKC_eta	356..678	CDD:270742	167/325 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000