DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and prkcdb

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001352166.1	Gene:	prkcdb / 100150844	ZFINID:	ZDB-GENE-111129-1	Length:	685	Species:	Danio rerio

Alignment Length:	660	Identity:	238/660 - (36%)
Similarity:	338/660 - (51%)	Gaps:	132/660 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVV 118
            || |:||:|:..:..:..|.|...|||.||:|..|::|:||..|||::|.:|...||:||...::
Zfish   143 NR-RRGAIKQAKVHFIKNHEFTATFFKQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKII 206

  Fly   119 FKCPG-----KDTDFDADCAKV--KHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHH 176
            .:|.|     :||.|..:..|:  .|.:.:..|.:|||||.||.||.|:..||:|||:|.:||||
Zfish   207 GRCTGTATNSRDTMFQKERFKIDMPHRFKTNNYMSPTFCDHCGSLLWGMVKQGLKCEDCGMNVHH 271

  Fly   177 ACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSG 241
            .||..|..:||     :..|||              .||.|.:.:
Zfish   272 KCQTKVANLCG-----INQKLL--------------AEALNQVSL-------------------- 297

  Fly   242 RTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPV 306
                  |:..|..:|..:|...:    |..||.:                             |.
Zfish   298 ------KSSTKRPDPTLSEIGIY----QAIDKNV-----------------------------PA 323

  Fly   307 DGWYKFLSQVEGEHYN-----IPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMI 366
            |      ...||..|.     .|.|.|...::.:|                             :
Zfish   324 D------PSAEGSQYGKFWDITPAVPASTIVSTVR-----------------------------V 353

  Fly   367 RAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPF 431
            ...||.|.||:||||||||:|||.:|..:.:|:|.|:|||::..||:|..|.||::|||:...||
Zfish   354 SLNDFVFQKVLGKGSFGKVMLAELKGKGQYFAIKALKKDVVLMDDDVECTMVEKRVLALAWENPF 418

  Fly   432 LVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDL 496
            |..::..||:.:.|||||||..|||||:|:|..|||....|.|||.|:...|.:||.:.|:||||
Zfish   419 LTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLYRATFYAAEIICGLQYLHSKGIVYRDL 483

  Fly   497 KLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLF 561
            ||||::||.:||:|:.|||:.||.:.......||||||:|:||||:....||.:.|||||||||:
Zfish   484 KLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEILLGQKYSFSVDWWSFGVLLY 548

  Fly   562 EFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLG-AGRYARQEITT 625
            |.:.||:||:||||..:|.:|:.....:|:..:.||.|::.....:.|..||| .|     .|..
Zfish   549 EMLIGQSPFQGDDEDELFDSIRMDVPHYPRWITKEAKDLLEKLFERDPTRRLGVVG-----NIRG 608

  Fly   626 HPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFS 690
            |.||:.::|...|..|:.||.||.:|...|.||||..|..||..|:.:||..:.::||..|.|||
Zfish   609 HAFFKTINWPALEKREVSPPFKPKVKSSSDCSNFDREFLSEKPRLSQSDKNLIDSMDQTAFAGFS 673

  Fly   691 FMNPEFITII 700
            |:||:..::|
Zfish   674 FINPKMESLI 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	23/56 (41%)
		C1_1	137..189	CDD:278556	27/51 (53%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	18/134 (13%)
		S_TKc	371..629	CDD:214567	124/258 (48%)
		STKc_PKC	375..692	CDD:270722	149/317 (47%)
prkcdb	NP_001352166.1	C1_1	160..209	CDD:278556	21/48 (44%)
		C1_1	232..284	CDD:278556	27/56 (48%)
		PKc_like	362..677	CDD:328722	150/319 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910