DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and akt2

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001116936.1	Gene:	akt2 / 100144709	XenbaseID:	XB-GENE-484168	Length:	485	Species:	Xenopus tropicalis

Alignment Length:	473	Identity:	163/473 - (34%)
Similarity:	248/473 - (52%)	Gaps:	57/473 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 KKKTKTIQKNLNPVFNETFTFELQ----PQDRDKRLLIEVWDW----DRTSRNDFMGSFSFSLEE 300
            |:|.::.:.:..|..|.....|.|    .:.|....:|....|    :||        |.....|
Frog    39 KEKPESTEHSSIPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERT--------FHVDTPE 95

  Fly   301 LQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIAR-LRDEVRHDRRPNEKRRMDNK---------- 354
            .::|    |                :.|...:|. |:::|..|   .|:..|:.|
Frog    96 EREE----W----------------IIAIQTVANGLKNQVAED---EEEEAMEVKYGSPSDVSSA 137

  Fly   355 -DMPHNMSK-RDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPM 417
             .|...||| |..:...||:::|::|||:||||:|...:.:...||:|:|||:|||..|::...:
Frog   138 EQMDVAMSKGRPKVTMNDFDYLKLLGKGTFGKVILVREKSSGRYYAMKILRKEVIIAKDEVAHTL 202

  Fly   418 NEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIA 482
            .|.::|. :.:.|||.::...|||.|||.|||||..||:|.:|:.:...|.|..|.||..|:..|
Frog   203 TESRVLQ-NTKHPFLTALKYAFQTSDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSA 266

  Fly   483 LFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPY 547
            |.:||.|:::|||:||:|::||.:||||:.||||.|||:|:..|.|||||||.|:|||::..:.|
Frog   267 LEYLHSRNVVYRDIKLENLMLDKDGHVKITDFGLCKEGITDGATMRTFCGTPEYLAPEVLEDNDY 331

  Fly   548 SIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNR 612
            ..|.|||..||:::|.|.|:.||...|...:|..|..::..||:..|.||..::...|.|.|..|
Frog   332 GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQR 396

  Fly   613 LGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLF 677
            ||.|....||:.:|.||.:::|......::.||.||.:....|...|||.||.:...|||.|:..
Frog   397 LGGGPNDAQEVMSHRFFASINWQDVTERKLTPPFKPQVTSEIDTRYFDDEFTAQSITLTPPDRYD 461

  Fly   678 MMNLDQND----FIGFSF 691
            .::..::|    |..||:
Frog   462 NLDALESDQRPHFPQFSY 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556
		C1_1	137..189	CDD:278556
		C2_PKC_alpha_gamma	194..324	CDD:175992	15/87 (17%)
		S_TKc	371..629	CDD:214567	113/257 (44%)
		STKc_PKC	375..692	CDD:270722	133/321 (41%)
akt2	NP_001116936.1	PH_PKB	4..112	CDD:269947	17/100 (17%)
akt2	NP_001116936.1	STKc_PKB_beta	160..482	CDD:173686	133/321 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010