DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaC and prkcha

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001116528.1	Gene:	prkcha / 100144561	ZFINID:	ZDB-GENE-080402-5	Length:	712	Species:	Danio rerio

Alignment Length:	677	Identity:	242/677 - (35%)
Similarity:	349/677 - (51%)	Gaps:	141/677 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GNLLEITGEANIVNYMK-NRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWG-FGKQG 99
            |:.::.....|...|.: ||.|:.|::|| :..||||:|...|.|.||:|.|||:|||| |||||
Zfish   134 GSFIDEDAGGNARPYKEFNRKRQQAVRRK-IHQVNGHKFMSTFLKQPTFCFHCKEFIWGVFGKQG 197

  Fly   100 FQCEECRFNIHQKCCKFVVFKCP------GKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLLH 158
            :||:.|...:|::|.:.||..||      .:.:........|.|.:....|..|||||.||.||.
Zfish   198 YQCQVCTCVVHKRCHQLVVTVCPRMKKPAKEQSTTQGFSINVPHKFSIHNYKVPTFCDHCGSLLW 262

  Fly   159 GVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDT 223
            |:..||:.|:.|.:|||..|:..|.|.||.:..|:..||.
Zfish   263 GIVRQGLHCKICKMNVHIRCKGNVAPNCGINNVELANKLA------------------------- 302

  Fly   224 NGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRN 288
                                                   ...|||....||..:.:...|..||.
Zfish   303 ---------------------------------------EMGLQPGGLTKRNSVGLAGLDAQSRT 328

  Fly   289 DFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDN 353
                                    || |.||
Zfish   329 ------------------------LS-VRGE---------------------------------- 334

  Fly   354 KDMPHNMSKRDM---IRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMEL 415
                ...||::.   :..::|..::|:||||||||:|....|:|:::|||:|:||:|:|.||:|.
Zfish   335 ----RGQSKKEQCLKLGISNFTLLQVLGKGSFGKVMLVRLNGSDQVFAVKILKKDIILQDDDVEC 395

  Fly   416 PMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVA 480
            .|.||::|:|:...|:|..::.||||.:|||||||:..|||||:|:|:..:|:|:.|.||..|:.
Zfish   396 TMTEKRVLSLASTHPYLTQLYCCFQTPERLFFVMEFVNGGDLMFHIQKSRKFEENRARFYTAEIT 460

  Fly   481 IALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYD 545
            .||.|||.:.|:||||||||:|||.:||.||.|||:.|||:.:...|.||||||:|:||||:...
Zfish   461 SALIFLHSKGIVYRDLKLDNVLLDKDGHCKLADFGMCKEGMFDGIVTGTFCGTPDYIAPEILQEL 525

  Fly   546 PYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPN 610
            .|..:.|||:.||||:|.::|.||||.::|..:|.:|..::.::....|..|:||:..||||.|:
Zfish   526 LYGPSVDWWALGVLLYEMLSGHAPFEAENEDDLFESILTEEIIYASWLSTNAVDILKGFLTKNPS 590

  Fly   611 NRLG--AGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPT 673
            .|||  |.......:|.||||.::||||.:...:|||.||.||..:|::|||..||:|...|||.
Zfish   591 RRLGCVATEGGETAVTGHPFFTDIDWDKLDQRALEPPFKPRIKTAEDVNNFDPDFTQEDPTLTPI 655

  Fly   674 DKLFMMNLDQNDFIGFSFMNPEFITII 700
            |:..:.::.|:||.||||.:.|.:.::
Zfish   656 DESILPSISQDDFRGFSFTSSELLKMV 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	28/58 (48%)
		C1_1	137..189	CDD:278556	24/51 (47%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	15/129 (12%)
		S_TKc	371..629	CDD:214567	127/259 (49%)
		STKc_PKC	375..692	CDD:270722	156/318 (49%)
prkcha	NP_001116528.1	C2_PKC_epsilon	3..136	CDD:175981	1/1 (100%)
		C1_1	169..220	CDD:278556	26/50 (52%)
		C1_1	241..293	CDD:278556	24/51 (47%)
		S_TKc	351..611	CDD:214567	127/259 (49%)
		PKc_like	355..678	CDD:304357	157/322 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840