DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaC and prkcq

DIOPT Version :9

Sequence 1:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	XP_012813823.2	Gene:	prkcq / 100038268	XenbaseID:	XB-GENE-487643	Length:	699	Species:	Xenopus tropicalis

Alignment Length:	658	Identity:	235/658 - (35%)
Similarity:	351/658 - (53%)	Gaps:	115/658 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 RKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKC 121
            |:||||:..:..|..|.|...||..||:|..|.:|:||..|||:||.:|...||:||...|:.||
Frog   142 RRGAMKQAKVHQVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKC 206

  Fly   122 PG-----KDTDFDADCAKV--KHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQ 179
            .|     |:|....:..|:  .|.:....|.:||||:.||.||.|:|.||:||..||:||||.|.
Frog   207 TGSAVNSKETVLHKERFKIDMPHRFKVNNYRSPTFCEHCGTLLWGLARQGLKCAECNMNVHHKCA 271

  Fly   180 ETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTK 244
            ..|..:||     |..||:                |..|..::|.              :..|.:
Frog   272 VKVANLCG-----VNQKLM----------------AEALAMIETT--------------QQDRRQ 301

  Fly   245 KKTKTIQK----NLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMG-SFSFSLE--ELQ 302
            :.::.|.:    |:.|..|          .:|:.:::.:       :.:..| |:...:|  ::|
Frog   302 RDSEFIYREGPVNVGPTTN----------TQDQPIVLSI-------KKESQGISWESPIESIKVQ 349

  Fly   303 KEPVDGWYKFLSQVEGEHYNIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMIR 367
            :.|                                       |..:.:::..      |.:..:.
Frog   350 ESP---------------------------------------PEPELKIEQS------SCQIKVT 369

  Fly   368 AADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFL 432
            .:||...|::||||||||.|||.:.|::.:|:|||:|||::..||:|..|.||::|:|:...|||
Frog   370 FSDFVLHKMLGKGSFGKVFLAELKRTNQFFAIKVLKKDVVLMDDDVECTMVEKRVLSLAWEHPFL 434

  Fly   433 VSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLK 497
            ..::..|||.:.|||||||..|||||:|:|...:|....|.|||.|:...|.|||.:.::|||||
Frog   435 THLYCTFQTKEHLFFVMEYLNGGDLMFHIQSCHKFDLPRATFYAAEIVCGLQFLHSKGVVYRDLK 499

  Fly   498 LDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFE 562
            |||||||.|||:|:.|||:.||.:.....|.||||||:|:||||:....|:.:.|||||||||:|
Frog   500 LDNILLDMEGHIKIADFGMCKESMLGDAKTSTFCGTPDYIAPEILLGQKYNYSVDWWSFGVLLYE 564

  Fly   563 FMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHP 627
            .:.||:||.|.||..:|::|:....::|:..|:||.||:.....::|..|||    .:.:|..|.
Frog   565 MLIGQSPFHGIDEEELFQSIRMDNPMYPRFLSMEAKDILIMLFVREPERRLG----VKGDIRQHC 625

  Fly   628 FFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFM 692
            ||:::||.:.|..|:|||.||.:|...|.||||..|..||..|:.:::..:.::|||.|..|||:
Frog   626 FFQHIDWGRLENREIEPPFKPKVKSADDWSNFDKEFLNEKPRLSSSERTLINSMDQNMFNNFSFV 690

  Fly   693 NPEFITII 700
            ||:...|:
Frog   691 NPKMEAIV 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaC	NP_476863.1	C1_1	72..124	CDD:278556	25/56 (45%)
		C1_1	137..189	CDD:278556	26/51 (51%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	16/136 (12%)
		S_TKc	371..629	CDD:214567	124/257 (48%)
		STKc_PKC	375..692	CDD:270722	150/316 (47%)
prkcq	XP_012813823.2	C1_nPKC_theta-like_rpt1	150..210	CDD:410384	26/59 (44%)
		C1_nPKC_theta-like_rpt2	229..278	CDD:410387	24/48 (50%)
		STKc_nPKC_theta	367..697	CDD:270770	155/333 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910