DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6472 and PNLIPRP2

DIOPT Version :9

Sequence 1:	NP_611166.2	Gene:	CG6472 / 36895	FlyBaseID:	FBgn0034166	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_005387.3	Gene:	PNLIPRP2 / 5408	HGNCID:	9157	Length:	469	Species:	Homo sapiens

Alignment Length:	318	Identity:	111/318 - (34%)
Similarity:	158/318 - (49%)	Gaps:	49/318 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DIKFMLYTSRNRNSAQLLHLSDDARLAQSNFNFNYPLAIYLHGFSESATGERQSSQELKDAFLRR 107
            |.:|:|||:.|.|:.||:..::...:..|||..:......:|||.:.|  |.....::.......
Human    53 DTRFLLYTNENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKA--EDSWPSDMCKKMFEV 115

  Fly   108 GNYNVILIDW----SAMTAVPWYSNAVENLPVSGRYLARFLRFL-VDKGYPAKYIHLIGFSLGAE 167
            ...|.|.:||    .||     |:.||:|:.|.|...|..::.| ...||..:.:|:||.||||.
Human   116 EKVNCICVDWRHGSRAM-----YTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAH 175

  Fly   168 VAGFAGKQLQEWGIKLPRITALDPALPLFEGNSSNRRLSPSDARFVDVIHTDGGLL------GNP 226
            .|..||::|   |.::.|||.||||.|.|:......||.||||.||||||||...:      |..
Human   176 TAAEAGRRL---GGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFGMS 237

  Fly   227 APMGHADFYPNGGRPLQPGCAKQNIANN-------WLGI--IVGCSHQRAWEYFVESIAQPRGFP 282
            ..:||.||:||||:.: ||| |:|:.:.       |.||  .|.|:|.|::||:..|:..|.||.
Human   238 QKVGHLDFFPNGGKEM-PGC-KKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFL 300

  Fly   283 AQRCEPSDMFGICRE------PGGGPAFMGMGADPRIRGK-------FYLDTNDAKPF 327
            ...|...|.|   :|      |..|...||..|| :.:||       |:|:|.::..|
Human   301 GYPCASYDEF---QESKCFPCPAEGCPKMGHYAD-QFKGKTSAVEQTFFLNTGESGNF 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6472	NP_611166.2	Pancreat_lipase_like	43..323	CDD:238363	110/312 (35%)
PNLIPRP2	NP_005387.3	Lipase	18..354	CDD:395099	110/316 (35%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	93..105		5/13 (38%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	257..279		5/21 (24%)
		PLAT_PL	357..469	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145344
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940