DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6472 and LPL

DIOPT Version :10

Sequence 1:NP_611166.2 Gene:CG6472 / 36895 FlyBaseID:FBgn0034166 Length:389 Species:Drosophila melanogaster
Sequence 2:NP_000228.1 Gene:LPL / 4023 HGNCID:6677 Length:475 Species:Homo sapiens


Alignment Length:325 Identity:108/325 - (33%)
Similarity:155/325 - (47%) Gaps:59/325 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MVLTAASTLCNVFTFLLAGSPIFYSAAPRGSCSTCCAIKEREDI-----KFMLYTSRNRNSAQLL 60
            :|||.|..|.::             .|.||..:   |..:|.|.     ||.|.|..: .:....
Human     7 LVLTLAVWLQSL-------------TASRGGVA---AADQRRDFIDIESKFALRTPED-TAEDTC 54

  Fly    61 HLSDDA--RLAQSNFNFNYPLAIYLHGFSESATGERQSSQELKDAFLRRGNYNVILIDWSAMTAV 123
            ||....  .:|..:||.:....:.:||::.:...|....:.:...:.|..:.|||::|       
Human    55 HLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVD------- 112

  Fly   124 PWYSNAVENLPVSGRY-------LARFLRFLVDK-GYPAKYIHLIGFSLGAEVAGFAGKQLQEWG 180
             |.|.|.|:.|||..|       :|||:.::.:: .||...:||:|:||||..||.||....:  
Human   113 -WLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNK-- 174

  Fly   181 IKLPRITALDPALPLFEGNSSNRRLSPSDARFVDVIHT-----DGGLLGNPAPMGHADFYPNGGR 240
             |:.|||.||||.|.||...:..||||.||.||||:||     .|..:|...|:||.|.||||| 
Human   175 -KVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGG- 237

  Fly   241 PLQPGC----AKQNIANNWLGII---VGCSHQRAWEYFVESIA-QPRGFPAQRCEPSDMF--GIC 295
            ..||||    |.:.||...||.:   |.|||:|:...|::|:. :.....|.||...:.|  |:|
Human   238 TFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLC 302

  Fly   296  295
            Human   303  302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6472NP_611166.2 Pancreat_lipase_like 43..323 CDD:238363 98/283 (35%)
LPLNP_000228.1 Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189 32..53 5/21 (24%)
lipo_lipase 33..473 CDD:132274 98/283 (35%)
Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706 243..266 7/22 (32%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370 417..421
Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582 430..434
Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189 443..467
Blue background indicates that the domain is not in the aligned region.

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