DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6472 and Lpl

DIOPT Version :9

Sequence 1:NP_611166.2 Gene:CG6472 / 36895 FlyBaseID:FBgn0034166 Length:389 Species:Drosophila melanogaster
Sequence 2:NP_036730.1 Gene:Lpl / 24539 RGDID:3017 Length:474 Species:Rattus norvegicus


Alignment Length:381 Identity:118/381 - (30%)
Similarity:173/381 - (45%) Gaps:68/381 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 RGSCSTCCAIKEREDI--KFMLYTSRNRNSAQLLHLSDDARLAQSNFNFNY--PLAIYLHGFSES 89
            ||..:.....::..||  ||.|.|..: .:....||......:.||.:||:  ...:.:||::.:
  Rat    22 RGGVAAADGGRDFSDIESKFALRTPED-TAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVT 85

  Fly    90 ATGERQSSQELKDAFLRRGNYNVILIDWSAMTAVPWYSNAVENLPVSGRY-------LARFLRFL 147
            ...|....:.:...:.|..:.|||::|        |...|.::.|||..|       :|||:.:|
  Rat    86 GMYESWVPKLVAALYKREPDSNVIVVD--------WLYRAQQHYPVSAGYTKLVGNDVARFINWL 142

  Fly   148 VDK-GYPAKYIHLIGFSLGAEVAGFAGKQLQEWGIKLPRITALDPALPLFEGNSSNRRLSPSDAR 211
            .:: .||...:||:|:||||..||.||....:   |:.|||.||||.|.||...:..||||.||.
  Rat   143 EEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNK---KVNRITGLDPAGPNFEYAEAPSRLSPDDAD 204

  Fly   212 FVDVIHT-----DGGLLGNPAPMGHADFYPNGGRPLQPGC----AKQNIANNWLGII---VGCSH 264
            ||||:||     .|..:|...|:||.|.||||| ..||||    |.:.||...||.:   |.|||
  Rat   205 FVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGG-TFQPGCNIGEAIRVIAEKGLGDVDQLVKCSH 268

  Fly   265 QRAWEYFVESIA-QPRGFPAQRCEPSDMF--GIC------REPGGGPAFMGMGADPRIRGKFYLD 320
            :|:...|::|:. :.....|.||...:.|  |:|      |....|.....:.|  :...|.||.
  Rat   269 ERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNVGYEINKVRA--KRSSKMYLK 331

  Fly   321 TNDAKPF-----------------GRNSRARAIV---SLAPRLPIAYKLPPNATRQ 356
            |....|:                 .:|::|..|.   ::|....|.:.||..||.:
  Rat   332 TRSQMPYKVFHYQVKIHFSGTENDKQNNQAFEISLYGTVAESENIPFTLPEVATNK 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6472NP_611166.2 Pancreat_lipase_like 43..323 CDD:238363 106/312 (34%)
LplNP_036730.1 Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 32..53 6/21 (29%)
lipo_lipase 33..472 CDD:132274 116/370 (31%)
Pancreat_lipase_like 37..334 CDD:238363 105/311 (34%)
Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858 243..266 7/22 (32%)
PLAT_LPL 341..465 CDD:238856 9/47 (19%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858 417..421
Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858 430..434
Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858 443..467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166339023
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11610
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.940

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