DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6472 and Lpl

DIOPT Version :9

Sequence 1:	NP_611166.2	Gene:	CG6472 / 36895	FlyBaseID:	FBgn0034166	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_032535.2	Gene:	Lpl / 16956	MGIID:	96820	Length:	474	Species:	Mus musculus

Alignment Length:	294	Identity:	101/294 - (34%)
Similarity:	147/294 - (50%)	Gaps:	40/294 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RGSCSTCCAIKEREDI--KFMLYTSRNRNSAQLLHLSDDARLAQSNFNFNY--PLAIYLHGFSES 89
            ||..:...|.::..||  ||.|.|..: .:....||......:.||.:||:  ...:.:||::.:
Mouse    22 RGGVAAADAGRDFSDIESKFALRTPED-TAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVT 85

  Fly    90 ATGERQSSQELKDAFLRRGNYNVILIDWSAMTAVPWYSNAVENLPVSGRY-------LARFLRFL 147
            ...|....:.:...:.|..:.|||::|        |...|.::.|||..|       :|||:.::
Mouse    86 GMYESWVPKLVAALYKREPDSNVIVVD--------WLYRAQQHYPVSAGYTKLVGNDVARFINWM 142

  Fly   148 VDK-GYPAKYIHLIGFSLGAEVAGFAGKQLQEWGIKLPRITALDPALPLFEGNSSNRRLSPSDAR 211
            .:: .||...:||:|:||||..||.||....:   |:.|||.||||.|.||...:..||||.||.
Mouse   143 EEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNK---KVNRITGLDPAGPNFEYAEAPSRLSPDDAD 204

  Fly   212 FVDVIHT-----DGGLLGNPAPMGHADFYPNGGRPLQPGC----AKQNIANNWLGII---VGCSH 264
            ||||:||     .|..:|...|:||.|.||||| ..||||    |.:.||...||.:   |.|||
Mouse   205 FVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGG-TFQPGCNIGEAIRVIAERGLGDVDQLVKCSH 268

  Fly   265 QRAWEYFVESIA-QPRGFPAQRCEPSDMF--GIC 295
            :|:...|::|:. :.....|.||...:.|  |:|
Mouse   269 ERSIHLFIDSLLNEENPSKAYRCNSKEAFEKGLC 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6472	NP_611166.2	Pancreat_lipase_like	43..323	CDD:238363	98/280 (35%)
Lpl	NP_032535.2	Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	32..53		6/21 (29%)
		lipo_lipase	33..472	CDD:132274	98/283 (35%)
		Pancreat_lipase_like	37..334	CDD:238363	97/279 (35%)
		Essential for determining substrate specificity. /evidence=ECO:0000250\|UniProtKB:P06858	243..266		7/22 (32%)
		PLAT_LPL	341..465	CDD:238856
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250\|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250\|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250\|UniProtKB:P06858	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010