Protein Alignment Fen1 and EXO1

DIOPT Version :10

• Sequence 1: NP_523765.1
• Gene: Fen1 / 36887
• FlyBaseID: FBgn0025832
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_006018.4
• Gene: EXO1 / 9156
• HGNCID: 3511
• Length: 846
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 105/393 - (26%)
• Similarity: 169/393 - (43%)
• Gaps: 51/393 - (12%)

  Fly     1 MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLM 65
            |||.||.:.|    .:|.....::.:.|:.||:|....|::..||...:.|:     |:||...:
Human     1 MGIQGLLQFI----KEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAK-----GEPTDRYV 56

  Fly    66 GMFYRTIR-LLDNGIKPVYVFDG-KPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNR 128
            |...:.:. ||.:||||:.|||| ..|..|..|.::|..|:....|..:...:.......|.|.|
Human    57 GFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQLLREGKVSEARECFTR 121

  Fly   129 RLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLL-- 191
            . :.:|...|.:..:.....||..:.||.||:||.|.|.|||.|.|..|||.|.|.||..|::
Human   122 S-INITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILK 185

  Fly   192 -----RYLTYSEARKMPVKEFSYDKLLEGLAINNREFIDLCILLGCDYCESIKGIGPKRAIELIN 251
                 ..|...:||....::.       |......:|..:|||.||||..|::|||..:|.:::.
Human   186 MDQFGNGLEIDQARLGMCRQL-------GDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLR 243

  Fly   252 TYR--DIETILDNLD---SSKYTVPENW--NYKVARELFIEPEVAD---ADSIDLKWVEPDEEGL 306
            ...  ||..::..:.   ....||||::  .:..|...|:...|.|   ...|.|...|.|.:..
Human   244 LANNPDIVKVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAYEDDVDPE 308

  Fly   307 VKFLCGDRQFNEERVRNGAKKLMKSKQAQTQVRLDSFFKTLPSTPNATNAAKRKA-----EEAKK 366
            .....|  |:.::.:  ..:..:.:|...|..::|.:      .|:....|..::     :..:|
Human   309 TLSYAG--QYVDDSI--ALQIALGNKDINTFEQIDDY------NPDTAMPAHSRSHSWDDKTCQK 363

  Fly   367 SAN 369
            |||
Human   364 SAN 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fen1	NP_523765.1	PTZ00217	1..363	CDD:240317	101/385 (26%)
EXO1	NP_006018.4	PIN_EXO1	1..201	CDD:350207	66/209 (32%)
		N-domain	1..99		34/106 (32%)
		Interaction with MSH3. /evidence=ECO:0000269|PubMed:11427529	129..387		66/255 (26%)
		I-domain	138..229		35/97 (36%)
		H3TH_EXO1	213..289	CDD:188628	22/75 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..396
		Interaction with MLH1	388..490
		Nuclear localization signal	418..421
		Interaction with MSH2	600..846
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	618..781
		Interaction with MLH1	787..846