DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fen1 and Exo1

DIOPT Version :10

Sequence 1:NP_523765.1 Gene:Fen1 / 36887 FlyBaseID:FBgn0025832 Length:385 Species:Drosophila melanogaster
Sequence 2:NP_036142.2 Gene:Exo1 / 26909 MGIID:1349427 Length:837 Species:Mus musculus


Alignment Length:470 Identity:118/470 - (25%)
Similarity:182/470 - (38%) Gaps:105/470 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLM 65
            |||.||.:.|    .:|.....:|.:.|:.||:|....|::..||...:.|:     |:||...:
Mouse     1 MGIQGLLQFI----QEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAEKLAK-----GEPTDRYV 56

  Fly    66 GMFYRTIR-LLDNGIKPVYVFDG-KPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNR 128
            |...:.:. ||..|:||:.:||| ..|..|..|.::|..|:....|..:...:.......:.| .
Mouse    57 GFCMKFVNMLLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARDCF-A 120

  Fly   129 RLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLL-- 191
            |.:.:|...|.:..:....:||..:.||.||:||.|.|.|||.|.|..|||.|.|.||..|::  
Mouse   121 RSINITHAMAHKVIKAARALGVDCLVAPYEADAQLAYLNKAGIVQAVITEDSDLLAFGCKKVILK 185

  Fly   192 -----RYLTYSEARKMPVKEFSYDKLLEGLAINNREFIDLCILLGCDYCESIKGIGPKRAIELIN 251
                 ..|...:||....|:.       |......:|..:|||.||||..|::|||..:|.:::.
Mouse   186 MDQFGNGLEVDQARLGMCKQL-------GDVFTEEKFRYMCILSGCDYLASLRGIGLAKACKVLR 243

  Fly   252 TYR--DIETILDNLD---SSKYTVPENW--NYKVARELFIEPEVADADSIDLKWVEPDEEG---- 305
            ...  ||..::..:.   ....||||::  .:..|...|:...|  .|.|..|.|..:..|    
Mouse   244 LANNPDIVKVIKKIGHYLRMNITVPEDYITGFIRANNTFLYQLV--FDPIQRKLVPLNAYGDDVN 306

  Fly   306 ---------------LVKFLCGDRQFNE-ERVRNGAKKLM---------KSKQAQTQVRLDSFF- 344
                           .::...|:|..|. |::.:.:...|         ..|..|.....:|.: 
Mouse   307 PETLTYAGQYVGDSVALQIALGNRDVNTFEQIDDYSPDTMPAHSRSHSWNEKAGQKPPGTNSIWH 371

  Fly   345 ------------------KTLPST--------------PNATNAAKRKAEEA--------KKSAN 369
                              |..|||              |..:...||...||        :.|:.
Mouse   372 KNYCPRLEVNSVSHAPQLKEKPSTLGLKQVISTKGLNLPRKSCVLKRPRNEALAEDDLLSQYSSV 436

  Fly   370 NKKAKTSGGGRGRRP 384
            :||.|.:|.|.|..|
Mouse   437 SKKIKENGCGDGTSP 451

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fen1NP_523765.1 PTZ00217 1..363 CDD:240317 108/439 (25%)
Exo1NP_036142.2 PIN_EXO1 1..201 CDD:350207 64/209 (31%)
N-domain 1..99 33/106 (31%)
Interaction with MSH3. /evidence=ECO:0000250 129..386 64/265 (24%)
I-domain 138..229 36/97 (37%)
H3TH_EXO1 213..289 CDD:188628 22/77 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 345..367 3/21 (14%)
Interaction with MLH1. /evidence=ECO:0000250 387..488 17/65 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..477 5/12 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..589
Interaction with MSH2. /evidence=ECO:0000250 591..837
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 608..740
Interaction with MLH1. /evidence=ECO:0000250 778..837
Blue background indicates that the domain is not in the aligned region.

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