Protein Alignment Fen1 and Ercc5

DIOPT Version :10

• Sequence 1: NP_523765.1
• Gene: Fen1 / 36887
• FlyBaseID: FBgn0025832
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_035859.2
• Gene: Ercc5 / 22592
• MGIID: 103582
• Length: 1170
• Species: Mus musculus
• Alignment Length: 474
• Identity: 94/474 - (19%)
• Similarity: 152/474 - (32%)
• Gaps: 163/474 - (34%)

  Fly   301 LTEYWSHRITYCSSPKNYPRVFCWIYRHEGRKLKHEFRCHAVICSKESVALEISTILKENLAKAL 365
            ||:.|.         .:.||:.   ::|.      |......:.|....|.:::::|.:...:.|
Mouse    14 LTDAWK---------SSQPRLH---FQHS------ELMRSGRLVSLSMPAGDLNSLLPDEDGRRL 60

  Fly   366 REFKRDKLNRQNARLSLANSVYDNPSMPRR--------KIM--------LSVGANNYRPPLERSK 414
            ....:|.|        |:.|:.|....||:        :|.        |.:...|:...|||..
Mouse    61 YIGMKDHL--------LSTSLDDITQNPRKIYWPANPDRIQDCTMAGKTLEMDCANFLRVLERYN 117

  Fly   415 SA-----------PK---------LMAIEEMIGEEDEEE-EGE---DDGARALKVGSSTAAGSTA 455
            ..           |:         |.|.|:.:.:||.|. .|:   |...|     ::||.....
Mouse   118 QTHLYACGTGAFNPRCAFIPTNLFLRAEEQTLQDEDTESGRGKCPFDPHQR-----TATAIIDGE 177

  Fly   456 LEACCREDALFPST----TLGRRRCRRGHSIRRSRLRNSFKTPKDVEARAPRKNENIVHISPMNK 516
            |.|....|.|...|    :||.|     |.||..:..:::           .:....||::.|
Mouse   178 LYAGISSDFLSHDTAFIRSLGER-----HVIRTEQYDSTW-----------LQGAEFVHVTAM-- 224

  Fly   517 SVDSILDTISQEEGEEEEQEE---EERMNDGETAP--------------ETGGS----------Q 554
                     |:.:.||:::..   .||..:.|.|.              :.||.          |
Mouse   225 ---------SESDNEEDDKVYVFFTERAQEAEGAAGKVLYSRVARVCKNDIGGQRSLVNKWSTFQ 280

  Fly   555 PPEAAAKLGKASKLSHHSDSSEDDFESFMAHYNYNSSEPLSTELISYFDMKLNPTAVC--SMHDL 617
            .......:.....:..|.|..:|.|    ..:..:...||...|.:.....||.:|||  .|.|:
Mouse   281 KARIVCSVPGPDGIQTHFDKLQDIF----IQHGRDKKNPLVYGLFTTTSNVLNGSAVCVYRMQDI 341

  Fly   618 SQ-------HHHGSLPVTLEDTQRLALSLDDLDHYSLPAGVGEADDAALVGLR-TRELKDREDEL 674
            .:       |..|......|.|.|:.        |..|   |....:...|.| |||..|
Mouse   342 IRAFKGNFLHREGHQYKLTEYTGRVP--------YPRP---GTCPSSTYGGFRSTREYPD----- 390

  Fly   675 DRDEVFFNQDEVL--EMLR 691
              |.:||::...|  |::|
Mouse   391 --DVIFFSRTHPLMQEVVR 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fen1	NP_523765.1	PTZ00217	1..363	CDD:240317	10/61 (16%)
Ercc5	NP_035859.2	rad2	1..1028	CDD:273166	94/474 (20%)
		N-domain. /evidence=ECO:0000250|UniProtKB:P28715	1..78		16/89 (18%)
		DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000250|UniProtKB:P28715	31..67		5/35 (14%)
		Spacer region. /evidence=ECO:0000250|UniProtKB:P28715	79..784		78/383 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..479		31/126 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..587
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..701
		I-domain. /evidence=ECO:0000250|UniProtKB:P28715	785..880
		DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000250|UniProtKB:P28715	819..835
		DNA-binding, H2TH (helix-2turn-helix) motif which binds double-stranded DNA. /evidence=ECO:0000250|UniProtKB:P28715	847..879
		DNA-binding, may bind double-stranded DNA. /evidence=ECO:0000250|UniProtKB:P28715	911..917
		Interaction with PCNA. /evidence=ECO:0000250|UniProtKB:P28715	980..1008
		Interaction with ERCC6/CSB. /evidence=ECO:0000250|UniProtKB:P28715	1010..1170
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1146
		Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P28715	1049..1065
		Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P28715	1153..1170