DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fen1 and FEN1

DIOPT Version :10

Sequence 1:NP_523765.1 Gene:Fen1 / 36887 FlyBaseID:FBgn0025832 Length:385 Species:Drosophila melanogaster
Sequence 2:NP_004102.1 Gene:FEN1 / 2237 HGNCID:3650 Length:380 Species:Homo sapiens


Alignment Length:385 Identity:242/385 - (62%)
Similarity:302/385 - (78%) Gaps:5/385 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLM 65
            |||.||:|||||:||.||||:::|.:|||||||||||.:||||||||..|..|....|:.|||||
Human     1 MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLM 65

  Fly    66 GMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNRRL 130
            ||||||||:::||||||||||||||.|||||||||:|||.||||.|:.|..||.:..:|||.:||
Human    66 GMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRL 130

  Fly   131 VRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLT 195
            |:|||:|..|.|.||:|||:||:|||.||||.||||||||||||.||||||.|||||..|:|:||
Human   131 VKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLT 195

  Fly   196 YSEARKMPVKEFSYDKLLEGLAINNREFIDLCILLGCDYCESIKGIGPKRAIELINTYRDIETIL 260
            .|||:|:|::||...::|:.|.:|..:|:|||||||.||||||:|||||||::||..::.||.|:
Human   196 ASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIV 260

  Fly   261 DNLDSSKYTVPENWNYKVARELFIEPEVADADSIDLKWVEPDEEGLVKFLCGDRQFNEERVRNGA 325
            ..||.:||.|||||.:|.|.:||:||||.|.:|::|||.||:||.|:||:||::||:|||:|:|.
Human   261 RRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGV 325

  Fly   326 KKLMKSKQAQTQVRLDSFFKTLPSTPNATNAAKRKAEEAKKSANNKKAKTSGGGRGRRPK 385
            |:|.||:|..||.|||.|||...|    .::||||..|.|.| ..|||||...|:.:|.|
Human   326 KRLSKSRQGSTQGRLDDFFKVTGS----LSSAKRKEPEPKGS-TKKKAKTGAAGKFKRGK 380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fen1NP_523765.1 PTZ00217 1..363 CDD:240317 231/361 (64%)
FEN1NP_004102.1 PTZ00217 1..373 CDD:240317 239/376 (64%)
N-domain 1..104 76/102 (75%)
I-domain 122..253 86/130 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..380 27/57 (47%)
Interaction with PCNA. /evidence=ECO:0000269|PubMed:9305916 336..344 5/7 (71%)

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