Protein Alignment Fen1 and Gen1

DIOPT Version :10

• Sequence 1: NP_523765.1
• Gene: Fen1 / 36887
• FlyBaseID: FBgn0025832
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_796305.3
• Gene: Gen1 / 209334
• MGIID: 2443149
• Length: 908
• Species: Mus musculus
• Alignment Length: 356
• Identity: 86/356 - (24%)
• Similarity: 154/356 - (43%)
• Gaps: 71/356 - (19%)

  Fly     4 LGLSKLIADLAP--QAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMG 66
            :|::.|...|.|  |.|...::.   |:.:|:|.|:    ::...::....:.||.   ..||..
Mouse     1 MGVNDLWQILEPVKQHIHLQDLS---GKTIAVDLSL----WVCEAQTVKKMIGTVK---KPHLRN 55

  Fly    67 MFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNRRLV 131
            :|:|...|....:|.|:|.:|:||.||:..::||.:.|..     .:........|...|
Mouse    56 LFFRISYLTQMNVKLVFVMEGEPPMLKADVISKRTQTRYG-----PSGKSRSQKTGRSHF----- 110

  Fly   132 RVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTY 196
               |...:|..|:|..:|:|:|.|..||||.||.|..:|.|....|.|.||..:|:..:.|..|.
Mouse   111 ---KSVLRECLEMLECLGMPWVQAAGEAEAMCAYLNASGHVDGCLTNDGDAFLYGAQTVYRNFTM 172

  Fly   197 SEARKMP-VKEFSYDKLLEGLAINNREFIDLCILLGCDYC-ESIKGIGPKRAIELINTYRDIETI 259
            :  .|.| |..::...:...|.::....:.|.:||||||. :.:.|:|.::|::|:..::. :::
Mouse   173 N--TKDPHVDCYTISSIKSKLGLDRDALVGLAVLLGCDYLPKGVPGVGKEQALKLLQIFKG-QSL 234

  Fly   260 LDN----LDSSKYTVPENWNYKVAR-----------------------ELFIEPEVADADSI-DL 296
            |..    ::...|:||::...||..                       :.:.||.  |.|.: ..
Mouse   235 LQRFNQWIEDPCYSVPQSAPKKVVHCSVCSHPGSPKDHERNGCILCKSDKYCEPH--DYDYLCPC 297

  Fly   297 KWVEPDEEGLVKFLCGDRQFNEERVRNGAKK 327
            :|.:.|.         :|..:|  :.|..||
Mouse   298 EWHQTDH---------NRHLSE--IENNIKK 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fen1	NP_523765.1	PTZ00217	1..363	CDD:240317	86/356 (24%)
Gen1	NP_796305.3	PIN_GEN1	2..206	CDD:350217	60/228 (26%)
		XPG-N domain. /evidence=ECO:0000250|UniProtKB:Q17RS7	2..96		28/108 (26%)
		XPG-I domain. /evidence=ECO:0000250|UniProtKB:Q17RS7	122..208		28/87 (32%)
		H3TH_StructSpec-5'-nucleases	195..337	CDD:473957	28/137 (20%)
		5'-3' exonuclease domain. /evidence=ECO:0000250|UniProtKB:Q17RS7	208..383		23/124 (19%)
		Chromodomain. /evidence=ECO:0000250|UniProtKB:Q17RS7	389..463
		Chromo_2	397..457	CDD:465841
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	460..482
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..650
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	792..834
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	853..886