DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS8 and Ints8

DIOPT Version :9

Sequence 1:	NP_611162.2	Gene:	IntS8 / 36886	FlyBaseID:	FBgn0025830	Length:	1007	Species:	Drosophila melanogaster
Sequence 2:	NP_001153067.1	Gene:	Ints8 / 72656	MGIID:	1919906	Length:	995	Species:	Mus musculus

Alignment Length:	1081	Identity:	284/1081 - (26%)
Similarity:	479/1081 - (44%)	Gaps:	188/1081 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PLAAETVLWFEFLLDPHKITQHLQRPHPEPSAMELIVQFISMTPNTAQESVGTPGSDLQNLNQTP 75
            |.......||||||:...:.:||::..|:|:.::|||||:        |....|..:.||..|.|
Mouse    16 PCTPPQTCWFEFLLEESLLEKHLRKACPDPAPVQLIVQFL--------EQASKPSVNEQNQVQPP 72

  Fly    76 SNSGPIPGVVGGAPAPTTPTASGGVGMPHSPQRPAEKGLQLNRKQLALKILELKVATWLKWDLDA 140
            .:                                       |::...||:|.||||..||||||.
Mouse    73 PD---------------------------------------NKRNRVLKLLALKVAAHLKWDLDI 98

  Fly   141 LEKNLPVIMQLALLRDLCTISYGCSLSIPLPNDFDARISAAGNERAARFALTIYHRMLLRMQLIK 205
            |||:|.|.:...||.:|..||     .:| |......:..:........|:.:|:|..:|..:..
Mouse    99 LEKSLSVPVLNMLLNELLCIS-----KVP-PGTKHVDMDLSALPPTTAMAILLYNRWAIRTIVQS 157

  Fly   206 EQALKAPRPQNTMYQTVDQLQQFLDTPTQPSIEYLQQLCAS-----------TKPFYIFHYDSFV 259
            ...:|..:|.......::|:||..:. |:..::.|::..|.           .|..|:.
Mouse   158 SFPVKQAKPGPPQLNVMNQMQQEKEL-TENILKVLKEQAADCILVLEAALRLNKDLYVH------ 215

  Fly   260 PLRCDDI---------GNGQNYDVMHLITPQELRAQLHYELAQYYLY-----TKQYVLAREAAAA 310
            .:|..|:         |..:|......|..:|::.|:.|:|...|..     :..|..|||....
Mouse   216 TMRTLDLLAVEPGTVNGETENSTAGLKIRTEEMQCQVCYDLGAAYFQQGSTDSAIYENAREKFFR 280

  Fly   311 CNTNLQAIPPQTTLYYCHIRPSELEGLLQACGI----SAEEQSLLEKFQQSLL----NNYTDIVS 367
            ....|..|  .:...:|.|....|.|..|||.:    |......|..:.|..:    .:|.::|.
Mouse   281 TKELLAEI--GSLSLHCTIDEKRLAGYCQACDVLVPSSDNNSQQLTPYSQVHICLRSGSYQEVVQ 343

  Fly   368 ILRMDNRRREIPFISRRQVELDIEGSISTGILKETV-QLQLQVAALNVVRNIFEWGSIFGSVEYF 431
            |...||....:|...|:.|..::......|  .|.: ::..::...|.||::.|..:|  ||::.
Mouse   344 IFIEDNLTFTLPVQFRQSVLRELFQKAQQG--NEALDEICFKICVCNTVRDVLEGRTI--SVQFN 404

  Fly   432 EKYRELDCLPPLVEALQEMLPHCTFK---EQAA------LKHFLID-CLLHQGGQSRQLLQTVRG 486
            :.:     |.|..|.:..:|..|:..   |:|:      :..||.: ||   |.:..|.:..:..
Mouse   405 QLF-----LRPNKEKIDFLLEVCSRSINVEKASDSLKGNMAAFLKNVCL---GLEDLQYVFMISS 461

  Fly   487 FGLF----SSDELQDIDEQMLQATPPV-----PTNSL----ASLSDWMCHSKMSRVDVGALERQL 538
            ..||    ..:|.:.:.:||.:.:|.|     |..|.    ||.|          |::|.||.||
Mouse   462 HELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASAS----------VNIGQLEHQL 516

  Fly   539 ISCTNANTVRILLVKLCATAPGKPLWAINPSWDVPQPLKTLIMAMPVSFLQDFSYVLLGKARELA 603
            |...:...:|.:|::|......:..|.::..|:||....::|:.:..:..:|..|:|:.|....:
Mouse   517 ILSVDPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSSVILGIKDNLTRDLVYILMAKGLHCS 581

  Fly   604 TRGNYIDAVSMLS-----VLKSENQRQEMAANVQLMCKLITWEILHIQITQCLEEWHQKPLDLQS 663
            |..::..:..:.:     |.:...:.:::..|..|:..:.|.|   ..:.|..|   :.|.||.|
Mouse   582 TVKDFPHSKQLFTACLELVTEFSPKLRQVMLNEMLLLDIRTHE---AGVGQSGE---RPPSDLIS 640

  Fly   664 LGGRCKQCLGALQAGDSIVP-RPDILESCAIMLLNLTE-------FPPLLYLDKRAGP-LELPLA 719
                  :..|.|:.....:| |..:.|.|...:||..|       .|..|:   :..| ::|...
Mouse   641 ------RVRGYLEMRLPDIPLRQVVAEECVAFMLNWRENEYLTLQVPAFLF---QNNPYVKLGQL 696

  Fly   720 FAATFIEMEKMKGPKKVCRDAWELMLSM--FLNVPKRGSSG----------VGGI---SSLQAFL 769
            .|||..|:...|..::..:|.||:::.:  ..|..|||:.|          ..||   |.|.:|:
Mouse   697 LAATCKELPGPKESRRTAKDLWEVVVQICSVSNQHKRGNDGRVSLIKQRESTLGIMYRSELLSFI 761

  Fly   770 QRIRHQSVFGLAISMIGKVHNILKDDPNHDLSCEYMQLWPTSINNPVSYSLRSVCETLQWLLSEA 834
            :::|...|..:.:|:..|:||:.:|..| |::.|::.:||:||.|..|....:|..|::.|:...
Mouse   762 KKLREPLVLTIILSLFVKLHNVREDIVN-DITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYT 825

  Fly   835 LSYYPQTISWLKMKGDLDLAIGNNESAMRCYVNALVTGTDYCTMPLQRNVADDYVIRKMIRCAAN 899
            ||..|...:||.::.|:..|...:.:|:..|:.|....:|:....:..:|..|.||::||:|.:.
Mouse   826 LSINPNNHAWLIIQADIYFATNQHSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSL 890

  Fly   900 LGCHMQATVLCQFLDEIDYGIVFKNLSEKSSNFTDAMDAYYSCIWDTTLLEFIVNLHAKRGEHSR 964
            |.||.|..:|||||.||||...||:|.|::|:  ||||:||..|||.|:||::..||.||||..:
Mouse   891 LNCHTQVAILCQFLREIDYKTAFKSLQEQNSH--DAMDSYYDYIWDVTILEYLTYLHHKRGETDK 953

  Fly   965 KLEAISMMGTLELNANNNEEIKRESAMVRKSRFLRALAKQY 1005
            :..||..:|..||||:|.||:.:.:|..||.:||:|:||.|
Mouse   954 RQIAIKAIGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLY 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
IntS8	NP_611162.2	None
Ints8	NP_001153067.1	TPR 1	250..288	9/37 (24%)
		TPR 2	320..356	7/35 (20%)
		TPR 3	570..603	5/32 (16%)
		TPR 4	833..866	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849870
Domainoid	1	1.000	290	1.000	Domainoid score	I1538
eggNOG	1	0.900	-	-		E1_2CA0B
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9888
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2780
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46381
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008167
OrthoInspector	1	1.000	-	-		oto93040
orthoMCL	1	0.900	-	-		OOG6_106555
Panther	1	1.100	-	-	LDO	PTHR13350
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3335
SonicParanoid	1	1.000	-	-		X6130
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790