DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5550 and TNC

DIOPT Version :9

Sequence 1:	NP_001246376.1	Gene:	CG5550 / 36883	FlyBaseID:	FBgn0034160	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	XP_016870167.1	Gene:	TNC / 3371	HGNCID:	5318	Length:	2384	Species:	Homo sapiens

Alignment Length:	244	Identity:	95/244 - (38%)
Similarity:	135/244 - (55%)	Gaps:	34/244 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SLGLFYLASAEIGENVKIQTYKKYSSSCKE--LN-PKKSGVQKIQVGSD---VIEVYCDVTIAGK 70
            ::||.|                .:...|.:  || ...||:..|.:..|   .:||:||:|..|.
Human  2156 TIGLLY----------------PFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGG 2204

  Fly    71 GWLVVQRRVSVEENFYRNWTSYQTGFGDLKGNFFIGLNNLNKISSLQPQELYIELVDFAGEKRYA 135
            ||:|..||.:..||||:||.:|..||||.:..|::||:|||||::....||.::|.|. ||..:|
Human  2205 GWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDH-GETAFA 2268

  Fly   136 HYSVFHVGNVYSNYPITQLGAYSGTAGDSLSYHLYQPFSTFDRDNDNATINCAARYMGAWWYREC 200
            .|..|.||:..:.|.: ::..||||||||::||..:.|||||:|.|:|..|||..|.||:|||.|
Human  2269 VYDKFSVGDAKTRYKL-KVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNC 2332

  Fly   201 LSRIPCSNLNGAYLGGNHTDPALFGSGIVWGEWKGFTYSYKTVNIMVRP 249
             .|:   ||.|.|...||:      .|:.|..|||..:|.:...:.:||
Human  2333 -HRV---NLMGRYGDNNHS------QGVNWFHWKGHEHSIQFAEMKLRP 2371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5550	NP_001246376.1	FReD	34..250	CDD:238040	92/222 (41%)
TNC	XP_016870167.1	EGF_2	377..403	CDD:285248
		EGF_2	408..434	CDD:285248
		EGF_2	468..496	CDD:285248
		EGF_2	504..527	CDD:285248
		EGF_2	533..558	CDD:285248
		fn3	624..695	CDD:306538
		fn3	713..793	CDD:306538
		fn3	804..884	CDD:306538
		fn3	894..976	CDD:306538
		fn3	986..1064	CDD:306538
		fn3	1075..1154	CDD:306538
		fn3	1169..1241	CDD:306538
		fn3	1260..1327	CDD:306538
		fn3	1348..1427	CDD:306538
		fn3	1439..1508	CDD:306538
		fn3	1533..1605	CDD:306538
		fn3	1619..1691	CDD:306538
		fn3	1716..1788	CDD:306538
		fn3	1804..1883	CDD:306538
		fn3	1894..1973	CDD:306538
		fn3	1985..2055	CDD:306538
		fn3	2071..2143	CDD:306538
		Fibrinogen_C	2163..2372	CDD:278572	92/221 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	167	1.000	Domainoid score	I3858
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810