DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5550 and ANGPTL3

DIOPT Version :9

Sequence 1:	NP_001246376.1	Gene:	CG5550 / 36883	FlyBaseID:	FBgn0034160	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_055310.1	Gene:	ANGPTL3 / 27329	HGNCID:	491	Length:	460	Species:	Homo sapiens

Alignment Length:	205	Identity:	69/205 - (33%)
Similarity:	99/205 - (48%)	Gaps:	10/205 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SGVQKIQ-VGSDVIEVYCDVTIAGKGWLVVQRRVSVEENFYRNWTSYQTGFGDLKGNFFIGLNNL 110
            ||:..|: ..|.|..||||| |:|..|.::|.|:...:||...|.:|:.|||.|.|.|::||..:
Human   257 SGMYAIRPSNSQVFHVYCDV-ISGSPWTLIQHRIDGSQNFNETWENYKYGFGRLDGEFWLGLEKI 320

  Fly   111 NKISSLQPQELYIELVDFAGEKRYAHYSVFHVGNVYSNYPITQLGAYSGTAGDSLSYHLYQPFST 175
            ..|.......|.|||.|:...|.|..|| |::||..:||.: .|.|.:|...:::..:....|||
Human   321 YSIVKQSNYVLRIELEDWKDNKHYIEYS-FYLGNHETNYTL-HLVAITGNVPNAIPENKDLVFST 383

  Fly   176 FDRDNDNATINCAARYMGAWWYR-ECLSRIPCSNLNGAYLGGNHTDPALFGSGIVWGEWKGFTYS 239
            :|. ......||...|.|.||:. ||..    :||||.|.............|:.|....|..||
Human   384 WDH-KAKGHFNCPEGYSGGWWWHDECGE----NNLNGKYNKPRAKSKPERRRGLSWKSQNGRLYS 443

  Fly   240 YKTVNIMVRP 249
            .|:..:::.|
Human   444 IKSTKMLIHP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5550	NP_001246376.1	FReD	34..250	CDD:238040	69/205 (34%)
ANGPTL3	NP_055310.1	SMC_N	<84..>215	CDD:330553
ANGPTL3	NP_055310.1	FReD	243..453	CDD:238040	68/203 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810