DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5550 and FGG

DIOPT Version :9

Sequence 1:	NP_001246376.1	Gene:	CG5550 / 36883	FlyBaseID:	FBgn0034160	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_068656.2	Gene:	FGG / 2266	HGNCID:	3694	Length:	453	Species:	Homo sapiens

Alignment Length:	251	Identity:	74/251 - (29%)
Similarity:	115/251 - (45%)	Gaps:	35/251 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IQTYKKYSSSCKEL---NPKKSG---VQKIQVGSDVIEVYCDVTIAGKGWLVVQRRVSVEENFYR 87
            :|.:......|:::   ..|:||   ::.::.....: |||::..:|.||.|.|:|:....:|.:
Human   169 VQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFL-VYCEIDGSGNGWTVFQKRLDGSVDFKK 232

  Fly    88 NWTSYQTGFGDLK----GNFFIGLNNLNKIS--SLQPQELYIELVDFAGEKRYAHYSVFHVGNVY 146
            ||..|:.|||.|.    ..|::|...::.||  |..|..|.:||.|:.|....|.|::|.||...
Human   233 NWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEA 297

  Fly   147 SNYPITQLGAYSGTAGDS--------------LSYHLYQPFSTFDRDNDNATINCAARYMGAWWY 197
            ..|.:|......|.|||:              .:.|....|||:|.|||....|||.:....||.
Human   298 DKYRLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWM 362

  Fly   198 RECLSRIPCSNLNGAYL-GGNH---TDPALFGSGIVWGEWKGFTYSYKTVNIMVRP 249
            .:|    ...:|||.|. ||.:   :.|..:.:||:|..||...||.|...:.:.|
Human   363 NKC----HAGHLNGVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5550	NP_001246376.1	FReD	34..250	CDD:238040	73/246 (30%)
FGG	NP_068656.2	Fib_alpha	31..172	CDD:285864	1/2 (50%)
		FReD	175..414	CDD:294064	72/243 (30%)
		Gamma-chain polymerization, binding amino end of another fibrin alpha chain	400..422		4/15 (27%)
		Platelet aggregation and Staphylococcus clumping	423..437
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810