DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5550 and FGL2

DIOPT Version :9

Sequence 1:	NP_001246376.1	Gene:	CG5550 / 36883	FlyBaseID:	FBgn0034160	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_006673.1	Gene:	FGL2 / 10875	HGNCID:	3696	Length:	439	Species:	Homo sapiens

Alignment Length:	222	Identity:	79/222 - (35%)
Similarity:	114/222 - (51%)	Gaps:	32/222 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NPKKSGVQKIQVGSDVIEVYCDVTIAGKGWLVVQRRVSVEENFYRNWTSYQTGFGDLKGNFFIGL 107
            :||.|.          .|||||:...|.||.|:|.|:....||.|.|..|:.|||:|:..|::|.
Human   232 DPKNSS----------FEVYCDMETMGGGWTVLQARLDGSTNFTRTWQDYKAGFGNLRREFWLGN 286

  Fly   108 NNLNKISSLQPQELYIELVDFAGEKRYAHYSVFHVGNVYSNYPITQLGAYSGTAGDSLSY----- 167
            :.::.::..:...|.|:|.||.|.:.||.|..|:|.|.:..|.: .:|.|:|||||:|.:
Human   287 DKIHLLTKSKEMILRIDLEDFNGVELYALYDQFYVANEFLKYRL-HVGNYNGTAGDALRFNKHYN 350

  Fly   168 HLYQPFSTFDRDNDN-ATINCAARYMGAWWYRECLSRIPCSNLNGAYLGGNHTDPALFGSGIVWG 231
            |..:.|:|.|:|||. .:.||...|...||:..|||    :||||.|.   |.......:||.||
Human   351 HDLKFFTTPDKDNDRYPSGNCGLYYSSGWWFDACLS----ANLNGKYY---HQKYRGVRNGIFWG 408

  Fly   232 EWK--------GFTYSYKTVNIMVRPK 250
            .|.        |:..|:|...:|:|||
Human   409 TWPGVSEAHPGGYKSSFKEAKMMIRPK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5550	NP_001246376.1	FReD	34..250	CDD:238040	77/220 (35%)
FGL2	NP_006673.1	DUF460	<28..>161	CDD:331991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..126
		FReD	209..435	CDD:294064	77/220 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810