DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and RAPGEF5

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_036426.4	Gene:	RAPGEF5 / 9771	HGNCID:	16862	Length:	883	Species:	Homo sapiens

Alignment Length:	240	Identity:	59/240 - (24%)
Similarity:	113/240 - (47%)	Gaps:	18/240 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 LANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQR 234
            ||.::...|:.:|..|...||....::::....:|.|:....:|.|....|...|||...|..:|
Human   652 LALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKR 716

  Fly   235 AEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDN 299
            .:::..|||:|.......||:|.|||:..:.:||:.||::||..:..|.:..|..|..:.....|
Human   717 VQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLN 781

  Fly   300 WANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPHKG------GLEPEQRRNKMNNILRVISNYQ 358
            ....|...:.::.|.||::.|.|.|:.:|     |:|      .|...::.:.:.:.:|.:.:.:
Human   782 HKAYRDAFKKMKPPKIPFMPLLLKDVTFI-----HEGNKTFLDNLVNFEKLHMIADTVRTLRHCR 841

  Fly   359 QSNYKHL--QKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEP 401
            .:.:..|  ::|:..:.|:..:..|:..|.:||     .|..:||
Human   842 TNQFGDLSPKEHQELKSYVNHLYVIDSQQALFE-----LSHRIEP 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	57/237 (24%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
RAPGEF5	NP_036426.4	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910