DRSC/TRiP Functional Genomics Resources

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Protein Alignment RalGPS and RAPGEF2

DIOPT Version :10

Sequence 1:NP_725613.1 Gene:RalGPS / 36881 FlyBaseID:FBgn0034158 Length:702 Species:Drosophila melanogaster
Sequence 2:NP_001338653.1 Gene:RAPGEF2 / 9693 HGNCID:16854 Length:1685 Species:Homo sapiens


Alignment Length:568 Identity:120/568 - (21%)
Similarity:184/568 - (32%) Gaps:164/568 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 DNLRYSELSRKPTTDYNGYTGQAYAATQFKQSSPPPPPSQQQQQPTRVS-----KQRSPNTNGSA 73
            |..|.|.|.:||..|..  .||:       |........|.:..||.:.     ...:|:...|.
Human   699 DKTRISILPQKPYNDIG--IGQS-------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSH 754

  Fly    74 HTMACLRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKN-SIGCLNSF--SSSPDSPGCYYTIAA 135
            |.:..........:|.:.......|:...:..|.|..|. .|..:..|  :::||.    |::..
Human   755 HRILDFSATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQ----YSLCE 815

  Fly   136 SAAPPS---KSQSLPAHASIKQLDAVILSA------------------------------LRVPA 167
            .:..|.   |.:.||...| |..|.:.||.                              |::..
Human   816 VSVTPEGVIKQRRLPDQLS-KLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLST 879

  Fly   168 DVLANQITLLDFPVFAQIQPDEL----------SSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTV 222
            ..:|.|:::.:|.:|..|:|.|.          :|||           |:..|.:..|..:||..
Human   880 VEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCA-----------NLKRFEEVINQETFWVA 933

  Fly   223 QEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAF 287
            .|||......:|.:||.||||:|....|..|.:|:|||||.:..|.:.||..||..|..|....|
Human   934 SEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLF 998

  Fly   288 DRLSDIFSDQDNWANLRSYLES--LRLPCIPYLGLFLTDLIYIDLAHPHK--------------- 335
            ..|.|:|....|.|..|:.|.|  |:.|.||...:...||.::...:..|               
Human   999 QDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAK 1063

  Fly   336 -----------------------------------------------GGLEPEQRRNKMNNILRV 353
                                                           ||.:...||:...|..::
Human  1064 EIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKL 1128

  Fly   354 ISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSGPSSSSCSSKESF 418
                    |:..|.....::||:::    ||: :.||.....||..|||:.:.|.:.........
Human  1129 --------YEDAQMARKVKQYLSNL----ELE-MDEESLQTLSLQCEPATNTLPKNPGDKKPVKS 1180

  Fly   419 NVEVVTPALGCLNLS-----------PAKTIGSMRMASGTKFVPGHRK 455
            ....|.|..|....:           ||..|............|..:|
Human  1181 ETSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKK 1228

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RalGPSNP_725613.1 RasGEF 169..335 CDD:459872 56/177 (32%)
PH_RalGPS1_2 578..692 CDD:270120
RAPGEF2NP_001338653.1 CAP_ED 37..143 CDD:237999
cNMP 297..412 CDD:197516
RasGEFN 428..541 CDD:214571
PDZ_RapGEF2_RapGEF6-like 545..627 CDD:467237
RA_PDZ-GEF1 769..851 CDD:340483 19/86 (22%)
RasGEF 874..1099 CDD:238087 58/235 (25%)
Blue background indicates that the domain is not in the aligned region.

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