Protein Alignment RalGPS and RALGPS1

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001309254.1
• Gene: RALGPS1 / 9649
• HGNCID: 16851
• Length: 607
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 247/647 - (38%)
• Similarity: 340/647 - (52%)
• Gaps: 133/647 - (20%)

  Fly   128 GCYYTIAASAAPP---SKSQSLPAHA---SIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQ 186
            |...::..::|.|   |.|.||...:   :.|..|||:...|:|..:..|:||||:|.|||..||
Human     6 GLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQ 70

  Fly   187 PDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHEL 251
            |:||:||.|:||:||...||:||||:|||..|||.|:|||.|:..|.||||::||:|:||||.||
Human    71 PEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLEL 135

  Fly   252 NNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRL-PCI 315
            ||||||.:::||:|||.|:|||||||.|::||:..|::|..:.|.:||:...|.|:.||:: |.|
Human   136 NNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSI 200

  Fly   316 PYLGLFLTDLIYIDLAHPHKGG-LEPEQRRNKMNNILRVISNYQQS-NYKHLQKHEATQKYLTSI 378
            ||||::|.||||||.|:|..|. :|.|||.|:||||||:|::.|.| :|.||......||||.|:
Human   201 PYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSV 265

  Fly   379 RYIEELQNIFEEDQYKRSLNLEPASPS-----------GPSSSSCSSKESFNVEVVTPALGCLNL 432
            |||||||...|:|.||.||.:||.|.|           |||:.|.|::.|..     |.  |.:.
Human   266 RYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRR-----PT--CPDT 323

  Fly   433 SPAKTIGSMRMASGTKFVPGHRKCRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRC 497
            |.|   ||:    .|..||.|||..|||                              :|..|:.
Human   324 SVA---GSL----PTPPVPRHRKSHSLG------------------------------NNMMCQL 351

  Fly   498 RRIFGKIATHNHSDGHPHHLHLELDPSQVQPRHHLLDDSVLE-----------HSDALSQA-DLT 550
            ..:..|.||.               ||  :...|||||||||           .|.|::.. .|.
Human   352 SVVESKSATF---------------PS--EKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLG 399

  Fly   551 SLESAE-------GI-------------------------MCDFTGSD---CDLMSPEAAAAMHG 580
            |.||:|       |:                         .|.::.:.   |.|.:..|...|.|
Human   400 SSESSEFSEEMSSGLESRGRLYATLGPNWRVPVRNSPRTRSCVYSPTGPCICSLGNSAAVPTMEG 464

  Fly   581 CVRRKTVQKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERNDFKREPCKVCPLDGWYAHVS 645
            .:||||:.|||||||::||.|||:.:..::|:|:..||.:|::|..:|..|.|...:.||...:.
Human   465 PLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLP 529

  Fly   646 DNTKHKNTFELCHRTLGTVYRFRTDSPQMTHLWSNAICKLATMRVPK-----PLPTNLMSFE 702
            |:.:|.:.|:|.:...|.||:|:|.|.....||...:........|:     |.||...|.|
Human   530 DDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQEAGAAPGPTGTDSHE 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	98/166 (59%)
		PH_RalGPS1_2	578..692	CDD:270120	41/113 (36%)
RALGPS1	NP_001309254.1	RasGEF	46..288	CDD:214539	136/241 (56%)
		PH_RalGPS1_2	461..576	CDD:270120	41/114 (36%)