Protein Alignment RalGPS and ralgds

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001429469.1
• Gene: ralgds / 799483
• ZFINID: ZDB-GENE-081105-110
• Length: 837
• Species: Danio rerio
• Alignment Length: 663
• Identity: 141/663 - (21%)
• Similarity: 237/663 - (35%)
• Gaps: 210/663 - (31%)

  Fly    78 CLRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSK 142
            ||:...:|.:.......::.:|...|.....|::..:.......|.|           .|.|...
Zfish   214 CLQSLISYLQLNFSGSDLERRALNLLEHFQHRQQCEVEIEGDLCSCP-----------FATPEES 267

  Fly   143 S---QSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDK---- 200
            |   :..|:|            .:.....::|.|:|::|..:|.::.|.......|:::||
Zfish   268 SLEDEFSPSH------------FMSFSPSIVAEQLTVMDAELFKRVVPYHCLGGIWSQRDKKGKE 320

  Fly   201 HVNTPNIVAFTKRFNHTSFWTVQEILN--AEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISA 263
            |: .|.|.|...:||..:...:...|:  :.:|.|||:.|.|:|:||:|...|.:..||.||:||
Zfish   321 HL-APTIRATVSQFNSVTNCVIATCLDNRSLRPFQRAKRIEHWIEVARKCRILKSFSSLKAILSA 384

  Fly   264 MQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYL--------------------- 307
            :||.:|:||.:.|..:|::....|..||:||||.:|::..|..|
Zfish   385 LQSNAIHRLRRAWDDVSRESYRTFQELSEIFSDDNNYSLSRELLIKEGTSKSAIVEINHKGAQRR 449

  Fly   308 ------ESLRLPCIPYLGLFLTDLIYIDLA---HPHKGGLEPEQRRNKMNNILRVISNYQQSNYK 363
                  ..:....|||||.|||||:.:|.|   |...|.:..|:||.:...|.::.......||.
Zfish   450 HQQQRDMGVVQGTIPYLGTFLTDLVMLDTAMKDHLEVGLINFEKRRKEFEVIAQIKLLQLTCNYY 514

  Fly   364 HLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSGPSSSSCSSKESFNVEVVTPALG 428
            :..::   |:::...:.:|:|.   |.:.|..|.::||     ||.|.|.
Zfish   515 NFSRN---QRFIDWFKRVEKLT---ETESYSMSCDIEP-----PSESLCK--------------- 553

  Fly   429 CLNLSPAKTIGSM-RMA--SGTKFVPGHRKCRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTI 490
                   |..|.| ||:  ||......|.|
Zfish   554 -------KNGGIMKRMSEESGYSSAASHSK----------------------------------- 576

  Fly   491 SNKRCRCRRIFGKIATHNHSDGHPHHLHLELDPSQVQPRHHLLDDSVLEHSDALSQADLTSLESA 555
                                             |..|||.....|...:.:|:||   |||..|
Zfish   577 ---------------------------------SFEQPRLSQFKDCFKDGADSLS---LTSAGS- 604

  Fly   556 EGIMCDFTGSDCD-----LMSPEAAAAMHG--CVRRKTVQKEGRKPAVASWQRYWLQIWANSLVY 613
                   :|||.|     |.|||:.:....  .|:..:..:.|..|:.:|     .::|.:.
Zfish   605 -------SGSDADESLSLLNSPESGSQRTSTPTVKHSSTSETGELPSDSS-----TKLWESP--- 654

  Fly   614 FPPKSFKGSERNDFKREPCKVCPLDGWYAHVSDNTKHKN--------TFELCHRTLGTVYRFRTD 670
             .|.|.:.|...        :|...|..:..|.::...:        ||....|::..:..:.:.
Zfish   655 -TPSSLEASGSG--------LCLESGCSSSTSSSSSSSSSVSAFTGRTFNFHKRSVSGISDYSSL 710

  Fly   671 SPQMTHLWSNAIC 683
            |..:.:..:|..|
Zfish   711 SLPLYNQQANDCC 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	63/201 (31%)
		PH_RalGPS1_2	578..692	CDD:270120	17/116 (15%)
ralgds	NP_001429469.1	None