DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5522 and Ralgps2

DIOPT Version :9

Sequence 1:NP_725613.1 Gene:CG5522 / 36881 FlyBaseID:FBgn0034158 Length:702 Species:Drosophila melanogaster
Sequence 2:NP_001153437.1 Gene:Ralgps2 / 78255 MGIID:1925505 Length:590 Species:Mus musculus


Alignment Length:650 Identity:242/650 - (37%)
Similarity:330/650 - (50%) Gaps:150/650 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 TIAASAA-PPSKSQSLPAHAS--IKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSC 193
            ||||:.: ..|.|:||....|  .|..|||:...|:|..:..|.||||:|.|||..|||||||||
Mouse    12 TIAATVSEKSSSSESLSEKGSELKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQPDELSSC 76

  Fly   194 AWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLF 258
            .|.||:|:.:.||.||||:||||.|||.|:|||:|:..|.|||:::|:||.||||:||||||:|.
Mouse    77 GWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALM 141

  Fly   259 AIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRL-PCIPYLGLFL 322
            |::|.:|||.|:|||||||.||:||:..|::|..:.|.:||:..||.|:.||:: |||||||::|
Mouse   142 AVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYL 206

  Fly   323 TDLIYIDLAHPHKGG-LEPEQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQN 386
            :||.|||.|:|..|. ||.|||.|.||||||:||:.|||....:......||||.|::||||||.
Mouse   207 SDLTYIDSAYPSTGSILENEQRSNLMNNILRIISDLQQSCEYDIPILPHVQKYLNSVQYIEELQK 271

  Fly   387 IFEEDQYKRSLNLEPASPSGPSSSSCSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTK--- 448
            ..|:|.||.||.:||.: |.|.|:  :|:|    ::..|.:|.......|:..:...|:..:   
Mouse   272 FVEDDNYKLSLKIEPGA-STPRSA--ASRE----DLAGPDIGASPQGGRKSSAAAAAAAAAEGAL 329

  Fly   449 ----------FVP-GHRKCRSLG---------TKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNK 493
                      .:| |||||.|||         .:|:|::.|                        
Mouse   330 LPQTPPSPRNLIPHGHRKCHSLGYNFIHKMNTAEFKSATFP------------------------ 370

  Fly   494 RCRCRRIFGKIATHNHSDGHPHHLHLELDPSQVQPRHHLLDDSVLE-HSDALSQADLTSLESAEG 557
                                           ...|| |||||||:| |:.:..||:.::|.|...
Mouse   371 -------------------------------NAGPR-HLLDDSVMEPHAPSRGQAESSTLSSGIS 403

  Fly   558 IMCDFTGSDCDLMSPE-----------------------------------------------AA 575
            |    ..||...:|.|                                               .|
Mouse   404 I----GSSDGSELSEETSWPAFERNRLYHSLGPVTRVPRNGYRSHTKASSSAESEDLAVHLYPGA 464

  Fly   576 AAMHGCVRRKTVQKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERNDFKREPCKVCPLDGW 640
            ..:.|.:||||:.|||:||.||||.:||..:....|.|:..||.|.:||..||....|...:.||
Mouse   465 VTIQGVLRRKTLLKEGKKPTVASWTKYWAALCGTQLFYYAAKSLKATERKHFKSTSNKNVSVVGW 529

  Fly   641 YAHVSDNTKHKNTFELCHRTLGTVYRFRTDSPQMTHLW---SNAICKLATMRVPKPLPTNLMSFE 702
            ...::|:.:|.:.|.|.....|..|:|:..|.....||   .:|.|:....:|    |||||:||
Mouse   530 MVMMADDPEHPDLFLLTDSEKGNSYKFQAGSRMNAMLWFKHLSAACQSNKQQV----PTNLMTFE 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5522NP_725613.1 RasGEF 163..400 CDD:214539 137/238 (58%)
PH_RalGPS1_2 578..692 CDD:270120 41/116 (35%)
PH 578..685 CDD:278594 40/109 (37%)
Ralgps2NP_001153437.1 RasGEF 45..286 CDD:214539 137/240 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..319 8/37 (22%)
PXXP 331..334 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..413 12/36 (33%)
Required for stimulation of nucleotide exchange by RALA. /evidence=ECO:0000250 466..590 46/127 (36%)
PH_RalGPS1_2 466..581 CDD:270120 40/114 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 220 1.000 Domainoid score I2603
eggNOG 1 0.900 - - E1_KOG3417
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 373 1.000 Inparanoid score I2087
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49702
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003356
OrthoInspector 1 1.000 - - otm43898
orthoMCL 1 0.900 - - OOG6_104897
Panther 1 1.100 - - LDO PTHR23113
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5234
SonicParanoid 1 1.000 - - X2715
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.860

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