Protein Alignment RalGPS and rapgef6

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001361718.1
• Gene: rapgef6 / 733941
• XenbaseID: XB-GENE-981546
• Length: 1644
• Species: Xenopus tropicalis
• Alignment Length: 830
• Identity: 169/830 - (20%)
• Similarity: 281/830 - (33%)
• Gaps: 238/830 - (28%)

  Fly    14 DNLRYSELSRKPTTDYNGYTGQAYAATQFKQ-----SSPPPPPSQQQQQPTRVSKQRSPN----T 69
            |..|:|.|..||.:|.:....|..:....:|     :..|.|.:.....|..:  |.:.|    :
 Frog   683 DKTRFSILPPKPFSDGHVIQSQDDSIVGTRQCRHSVAIMPIPGTLSSSSPDLL--QATTNILDFS 745

  Fly    70 NGSAHTMACLRQE--KTYKEQQMEPPSMQPQASKTLNIKSTRRKN-SIGCLNSFSSSPDSPGCYY 131
            |.:|.....:..:  :.:|..|        |....:..|.|..|. .|..|:.||.: .|...|.
 Frog   746 NPTAFGFYYIPDQVIRIFKADQ--------QCCYIIIGKDTTAKEVVIQALHEFSLT-GSTDTYS 801

  Fly   132 TIAASAAPPS--KSQSLPAHASIKQLDAV------------------------------ILSALR 164
            ....|.:|..  |.:.||...| |..|.:                              ::|.|:
 Frog   802 LCEVSVSPEGVIKQRRLPDQLS-KLADRIQLNGRYYLKNNMETETLCSDEDAQELLRESLISLLQ 865

  Fly   165 VPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAE 229
            :....:|.|:::.||.:|..|:|.|.....: |.|...:..::..|.:..|..:||...|||...
 Frog   866 LSTIEVATQLSMRDFELFRNIEPTEYIDDLF-KIDSKTSAAHLKQFEEVINQETFWVATEILREP 929

  Fly   230 QPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIF 294
            ...:|.:|:.||||.|....|..|.:|:|||||.:..|.:.||..||..|..|.......|.|:|
 Frog   930 NHLKRMKIVKHFIKTALHCRECRNFNSMFAIISGLNLAPVARLRGTWEKLPSKYEKLLRDLQDLF 994

  Fly   295 SDQDNWANLRSYL--ESLRLPCIPYLGLFLTDLIYIDLAHPHKG--------------------- 336
            ....|.|..|:.|  :|::.|.||...:...|:.::     |:|
 Frog   995 DPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDITFL-----HEGNDSKVDGLVNFEKLRMIAKEI 1054

  Fly   337 ---------GLEP----EQRRNKMNNILRVISNYQQSN------------------------YKH 364
                     .::|    .||:.:..::..:......||                        |:.
 Frog  1055 RHVIRMTSANMDPAVMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGGHKKRARRSSFLNAKKLYED 1119

  Fly   365 LQKHEATQKYLT--SIRYIEE----------------LQNIFEEDQYKRSLNLEPASPSGPSSSS 411
            .|.....::|::  |:...||                .:|:.|....|..|:..|..|||.::.:
 Frog  1120 AQMSRKVKQYISNLSVEIDEEKIQLMSLQCEPAYSTLAKNLSERRSAKSDLSPAPLRPSGQTTKA 1184

  Fly   412 CSSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSLGTKFRSSSLPRNFAEKC 476
            ...:::...:|:  .:..:||.|      ||..:.||   .|..|.| |:..:.|.|......|.
 Frog  1185 HIHQQNRMSQVL--QVPTVNLYP------MRKKAPTK---EHLPCTS-GSSQKISGLTDEVTVKA 1237

  Fly   477 QCCIVMIAPGIGTISNKRCRCRRIFGKIATHNHS------DGHPHHL----------HLEL---- 521
            |     :...:..:|:.               ||      .|.||.:          |:.|
 Frog  1238 Q-----LEDSVSLVSSL---------------HSSPAASPQGSPHKVVNISRSENSSHMNLSGSS 1282

  Fly   522 -----DPSQ---------------VQPRHHLLDDSVLEHSDALSQADLTSLESAEGIMCDFTGSD 566
                 ||:|               ...:.....||  .:|:..|::.|.|..|.:.:........
 Frog  1283 SSLTSDPNQKICSRRGYGIGYAHNPSAKSDNFSDS--SNSEISSRSSLVSNCSVDSMSLTLQDEK 1345

  Fly   567 CDLMSPEAAAAMHGCVRRKTV--QKEGRKPAVASWQRYWLQIWANSLVYFPPKSFKGSERNDFKR 629
            |   .|.:.|...|...||.|  ..|..:|..:     ||.....::..|    ...:...|...
 Frog  1346 C---VPHSHAESMGLSERKDVHPSSEYNQPCSS-----WLHARHPAVRNF----IACASSEDIAH 1398

  Fly   630 EPCKVCPLD----GWYAHVSDNTKHKNTFELCHRTLGTVYRFR---TDSP 672
            :...|.|:|    .|.:  ..::.|.| |:...:.|..:..:|   .|||
 Frog  1399 DHISVEPVDSGRGSWTS--CSSSSHDN-FQTLQKGLDRLSTYRQSHIDSP 1445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	51/167 (31%)
		PH_RalGPS1_2	578..692	CDD:270120	22/104 (21%)
rapgef6	NP_001361718.1	CAP_ED	37..119	CDD:469590
		CAP_ED	280..380	CDD:237999
		RasGEFN	412..525	CDD:214571
		PDZ_RapGEF2_RapGEF6-like	529..611	CDD:467237
		RA_PDZ-GEF1	758..840	CDD:340483	20/91 (22%)
		RasGEF	863..1097	CDD:214539	59/239 (25%)