DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and SOS1

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_005624.2	Gene:	SOS1 / 6654	HGNCID:	11187	Length:	1333	Species:	Homo sapiens

Alignment Length:	317	Identity:	81/317 - (25%)
Similarity:	151/317 - (47%)	Gaps:	41/317 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQLDAVILSALR 164
            :|.:..|...|.|..|...:|.|||  |...:.|           |.|.|  |:..|.:.|..:.
Human   734 TKIIQRKKIARDNGPGHNITFQSSP--PTVEWHI-----------SRPGH--IETFDLLTLHPIE 783

  Fly   165 VPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAE 229
            :     |.|:|||:..::..:||.||....|||:||.:|:||::...:...:.:.|..:.|:..|
Human   784 I-----ARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETE 843

  Fly   230 QPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIF 294
            ..::|..:::..|::.:...||||.:.:..::|||.|:.:|||..|:..:..:.:...:...::
Human   844 NLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL- 907

  Fly   295 SDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHP-----HKGGLEPEQRRNKMNNILRVI 354
             .:|::....:.|.|:..||:|:.|::||:::..:..:|     |...|....:|.|:..|...|
Human   908 -SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEI 971

  Fly   355 SNYQQSNYKHLQKHEATQKYLTSIRYIEEL-------QNIFEEDQYKRSLNLEPASP 404
            ..||  |..:..:.|:..|     |:.|.|       :..|.:..:.:||.:||.:|
Human   972 QQYQ--NQPYCLRVESDIK-----RFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNP 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	61/248 (25%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
SOS1	NP_005624.2	Histone	63..169	CDD:333859
		RhoGEF	204..389	CDD:214619
		PH_SOS	439..545	CDD:269963
		RasGEFN	597..741	CDD:214571	1/6 (17%)
		RasGEF	776..1015	CDD:238087	61/252 (24%)
		PTZ00449	<1018..1319	CDD:185628	2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1103		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1333
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910