DRSC/TRiP Functional Genomics Resources

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Protein Alignment RalGPS and RASGRF2

DIOPT Version :10

Sequence 1:NP_725613.1 Gene:RalGPS / 36881 FlyBaseID:FBgn0034158 Length:702 Species:Drosophila melanogaster
Sequence 2:NP_008840.1 Gene:RASGRF2 / 5924 HGNCID:9876 Length:1237 Species:Homo sapiens


Alignment Length:510 Identity:124/510 - (24%)
Similarity:196/510 - (38%) Gaps:145/510 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 DLSTDNLRYSELSRKPTTDYNGYTGQAYAATQFKQSSPPPPPSQQQQQPTR--VSKQRSPNT--- 69
            ||:|        |..|||           .||...:||||...|.....:|  .|.::||.|   
Human   759 DLTT--------SSSPTT-----------TTQSPAASPPPHTGQIPLDLSRGLSSPEQSPGTVEE 804

  Fly    70 -NGSAHTMACLRQEKTYKEQQME--------------------PPSMQPQASKTLNIKSTRRKNS 113
             ..:.....|.:.:::.::..:|                    .|...|...:.|..   |:...
Human   805 NVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSPAADTTELSPCRSPSTPRHLRY---RQPGG 866

  Fly   114 IGCLNSFSSSPDSPGCYYTIAASAA----PPSKSQS-------------------------LPAH 149
            ....|:..|.  ||...:.||.:||    ||..:.:                         :..|
Human   867 QTADNAHCSV--SPASAFAIATAAAGHGSPPGFNNTERTCDKEFIIRRTATNRVLNVLRHWVSKH 929

  Fly   150 ASIKQLD----------------------------AVILSAL----------------------- 163
            |...:|:                            |.||.||                       
Human   930 AQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQDDIHLKLEDIIQMTDCMK 994

  Fly   164 -----RVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQ 223
                 .:.|..||.||||||..:|..|..:|.....|.|.||:..||.|:..::.||..|.....
Human   995 AECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVAS 1059

  Fly   224 EILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFD 288
            :|:|......||..|..::.||.....|:|.:.:..|.||:..::||||.||||.:||:.:...|
Human  1060 QIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMD 1124

  Fly   289 RLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPH--KGGLEPEQRRNKMNNIL 351
            :|....|.:..:.|||..|::...|.:||||::||||.:|:...|:  :.||....:...:::|:
Human  1125 KLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHII 1189

  Fly   352 RVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQ-YKRSLNLEPASPS 405
            |.|..:||::|:...:.:..|       |:.:...|.:||. |:.||.:||..|:
Human  1190 REIRQFQQTSYRIDHQPKVAQ-------YLLDKDLIIDEDTLYELSLKIEPRLPA 1237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RalGPSNP_725613.1 RasGEF 169..335 CDD:459872 61/167 (37%)
PH_RalGPS1_2 578..692 CDD:270120
RASGRF2NP_008840.1 PH_RasGRF1_2 19..158 CDD:270081
RhoGEF 247..428 CDD:214619
PH 480..588 CDD:214574
RasGEF_N 638..>686 CDD:459873
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..809 19/68 (28%)
Regulates proteasomal degradation. /evidence=ECO:0000250 744..752
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 829..873 5/46 (11%)
REM <901..972 CDD:470601 7/70 (10%)
RasGEF 998..1234 CDD:214539 79/242 (33%)
Responsible of the affinity for farnesylated versus geranylgeranylated Ras. /evidence=ECO:0000250 1099..1128 13/28 (46%)
Blue background indicates that the domain is not in the aligned region.

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