DRSC/TRiP Functional Genomics Resources

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Protein Alignment RalGPS and RALGDS

DIOPT Version :10

Sequence 1:NP_725613.1 Gene:RalGPS / 36881 FlyBaseID:FBgn0034158 Length:702 Species:Drosophila melanogaster
Sequence 2:NP_006257.1 Gene:RALGDS / 5900 HGNCID:9842 Length:914 Species:Homo sapiens


Alignment Length:582 Identity:139/582 - (23%)
Similarity:212/582 - (36%) Gaps:165/582 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KPTTDYNGYTGQAYAATQFKQSSPPPPPS-QQQQQPT-------RVSKQRSPNTNGSAHTMACLR 80
            |||.:..      .|.|..:..||.|.|: :.:..||       .|:...:|....:......| 
Human   268 KPTPELE------LALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGL- 325

  Fly    81 QEKTYKEQQMEP-PSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQ 144
            :.......::|| |...|..|:||.::                           .|.|..||...
Human   326 ESAPAPALELEPAPEQDPAPSQTLELE---------------------------PAPAPVPSLQP 363

  Fly   145 SLPAHASIKQ-LDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDK----HVNT 204
            |.|:....:. |.......|..|.|::|.|.||:|..:|.::.|.......|:::||    |: .
Human   364 SWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHL-A 427

  Fly   205 PNIVAFTKRFNHTSFWTVQEILNAEQPK--QRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSA 267
            |.|.|...:||..:...:...|.....|  .||.::.|:|:||::...|.|..||:||:||:||.
Human   428 PTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSN 492

  Fly   268 SIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYL----------------ESLRLP--- 313
            ||:||.|||..:|:.....|.:||:||||::|::..|..|                .:.:.|   
Human   493 SIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKET 557

  Fly   314 -----CIPYLGLFLTDLIYIDLAHPH--KGGLEPEQRRNKMNNILRVISNYQQ--SNYKHLQKHE 369
                 .:||||.|||||:.:|.|...  .|.|...::|.|...::..|...|.  :||    ...
Human   558 GIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNY----SIA 618

  Fly   370 ATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPS----------------------------- 405
            ..:::....|.:|.|.   |.:.|..|..|||.|.|                             
Human   619 PDEQFGAWFRAVERLS---ETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELST 680

  Fly   406 --------------GP---------------SSSSCSSKESFNVEVV------------------ 423
                          ||               :.||.|..|..|:..|                  
Human   681 SGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQS 745

  Fly   424 TPALGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSL-GTKFRSSSLPRNFAEKCQCCIVMIA 484
            :|...  .:|.|.:..|...||.|.........||: |....||:||....:...|||:.::
Human   746 SPETS--GISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVS 805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RalGPSNP_725613.1 RasGEF 169..335 CDD:459872 64/197 (32%)
PH_RalGPS1_2 578..692 CDD:270120
RALGDSNP_006257.1 RasGEFN 112..248 CDD:214571
PRK12323 <251..>399 CDD:481241 35/164 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..365 20/112 (18%)
GGN <304..358 CDD:434857 12/81 (15%)
RasGEF 382..644 CDD:238087 81/269 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 666..689 0/22 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 728..776 7/49 (14%)
RA_RalGDS 798..883 CDD:340729 3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

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