Protein Alignment CG5522 and RALGDS

DIOPT Version :9

• Sequence 1: NP_725613.1
• Gene: CG5522 / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_006257.1
• Gene: RALGDS / 5900
• HGNCID: 9842
• Length: 914
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 139/582 - (23%)
• Similarity: 212/582 - (36%)
• Gaps: 165/582 - (28%)

  Fly    24 KPTTDYNGYTGQAYAATQFKQSSPPPPPS-QQQQQPT-------RVSKQRSPNTNGSAHTMACLR 80
            |||.:..      .|.|..:..||.|.|: :.:..||       .|:...:|....:......|
Human   268 KPTPELE------LALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGL- 325

  Fly    81 QEKTYKEQQMEP-PSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQ 144
            :.......::|| |...|..|:||.::                           .|.|..||...
Human   326 ESAPAPALELEPAPEQDPAPSQTLELE---------------------------PAPAPVPSLQP 363

  Fly   145 SLPAHASIKQ-LDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDK----HVNT 204
            |.|:....:. |.......|..|.|::|.|.||:|..:|.::.|.......|:::||    |: .
Human   364 SWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHL-A 427

  Fly   205 PNIVAFTKRFNHTSFWTVQEILNAEQPK--QRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSA 267
            |.|.|...:||..:...:...|.....|  .||.::.|:|:||::...|.|..||:||:||:||.
Human   428 PTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSN 492

  Fly   268 SIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYL----------------ESLRLP--- 313
            ||:||.|||..:|:.....|.:||:||||::|::..|..|                .:.:.|
Human   493 SIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKET 557

  Fly   314 -----CIPYLGLFLTDLIYIDLAHPH--KGGLEPEQRRNKMNNILRVISNYQQ--SNYKHLQKHE 369
                 .:||||.|||||:.:|.|...  .|.|...::|.|...::..|...|.  :||    ...
Human   558 GIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNY----SIA 618

  Fly   370 ATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPS----------------------------- 405
            ..:::....|.:|.|.   |.:.|..|..|||.|.|
Human   619 PDEQFGAWFRAVERLS---ETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELST 680

  Fly   406 --------------GP---------------SSSSCSSKESFNVEVV------------------ 423
                          ||               :.||.|..|..|:..|
Human   681 SGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQS 745

  Fly   424 TPALGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSL-GTKFRSSSLPRNFAEKCQCCIVMIA 484
            :|...  .:|.|.:..|...||.|.........||: |....||:||....:...|||:.::
Human   746 SPETS--GISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVS 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	81/270 (30%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
RALGDS	NP_006257.1	RasGEFN	112..248	CDD:214571
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	280..365		20/112 (18%)
		RasGEF	382..644	CDD:238087	81/269 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	666..689		0/22 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	728..776		7/49 (14%)
		RalGDS_RA	798..883	CDD:176351	3/8 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910