Protein Alignment RalGPS and RGL2

DIOPT Version :10

• Sequence 1: NP_725613.1
• Gene: RalGPS / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: XP_047275155.1
• Gene: RGL2 / 5863
• HGNCID: 9769
• Length: 800
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 129/563 - (22%)
• Similarity: 205/563 - (36%)
• Gaps: 173/563 - (30%)

  Fly   123 SPDSPGCYYTIAASAAPPSKSQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQP 187
            :||.|              |..:||........|.::..     ||.||.|:||||..:|..:.|
Human   242 APDLP--------------KPLALPGDPPADPTDVLVFL-----ADHLAEQLTLLDAELFLNLIP 287

  Fly   188 DELSSCAWTKKDK----HVNTPNIVAFTKRFNHTSFWTVQEILNAE--------------QPKQR 234
            .:.....|..:|:    |: .|::.|...:||..:...|..:|.|.              :|.||
Human   288 SQCLGGLWGHRDRPGHSHL-CPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQR 351

  Fly   235 AEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDN 299
            |.::..:|:||::...|.|..|::|::||:||:.|:||...|...::.....|..|..|||::||
Human   352 ARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDN 416

  Fly   300 WANLRSYL------------ESLRLP--------CIPYLGLFLTDLIYIDLAHP---HKGGLEPE 341
            ::..|..|            .|.:.|        .:||||.||.||:.:|.|..   ..|.:..:
Human   417 YSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFD 481

  Fly   342 QRRNKMNNI--LRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASP 404
            :||.:...:  ||.:.|  :....:||.....|::|..:|.:.|.|:      ::.|..:||...
Human   482 KRRKEFAVLSELRRLQN--ECRGYNLQPDHDIQRWLQGLRPLTEAQS------HRVSCEVEPPGS 538

  Fly   405 SGPSSS---------SCSSKESFNVEVVTPALGC---------LNLSPAKTIGSMRMASGTKFVP 451
            |.|.:.         |..::...:|.|.||.:.|         ...:||..:  .|:|...|:
Human   539 SDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLL--TRLAQHMKW-- 599

  Fly   452 GHRKCRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFGKIATHNHSDGHPHH 516
              ....||.:...||                  |.:                     ||...|.|
Human   600 --PSVSSLDSALESS------------------PSL---------------------HSPADPSH 623

  Fly   517 LHLELDPSQVQPRHHLLDDSVLEHSDALSQADLT-SLESAEGIMCDFTG----------SDCDLM 570
                |.|....||     .|......|...:.|: ..|.|.|    .||          |||.::
Human   624 ----LSPPASSPR-----PSRGHRRSASCGSPLSGGAEEASG----GTGYGGEGSGPGASDCRII 675

  Fly   571 SPEAAAAMHGCVRR---------------KTVQKEGRKPAVAS 598
            ..:......|.|.:               :.::|..|..||||
Human   676 RVQMELGEDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVAS 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RalGPS	NP_725613.1	RasGEF	169..335	CDD:459872	59/206 (29%)
		PH_RalGPS1_2	578..692	CDD:270120	8/36 (22%)
RGL2	XP_047275155.1	RasGEFN	113..235	CDD:214571
		RasGEF	262..536	CDD:214539	76/287 (26%)
		RA_RGL2	670..756	CDD:340731	11/49 (22%)