DRSC/TRiP Functional Genomics Resources

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Protein Alignment RalGPS and RGL3

DIOPT Version :10

Sequence 1:NP_725613.1 Gene:RalGPS / 36881 FlyBaseID:FBgn0034158 Length:702 Species:Drosophila melanogaster
Sequence 2:NP_001155088.2 Gene:RGL3 / 57139 HGNCID:30282 Length:716 Species:Homo sapiens


Alignment Length:521 Identity:126/521 - (24%)
Similarity:205/521 - (39%) Gaps:146/521 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PPPPPSQQQQQPTRVSKQRSPNTN----------------------------------------G 71
            |||||...:.:.|.| :..|.|.|                                        |
Human   118 PPPPPPGVEIKKTAV-QDLSFNKNLRAVVSVLGSWLQDHPQDFRDHPAHSDLGSVRTFLGWAAPG 181

  Fly    72 SAHTMACLR-----QEKTYKEQQMEPPSM---QPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPG 128
            ||......:     .|:..:||:.|||.:   .|:.::|                   |.|||  
Human   182 SAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQT-------------------SDPDS-- 225

  Fly   129 CYYTIAASAAPPSKSQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSC 193
                  :.|....:...:|....:          |....|.:|.|:||:|..:|::::..|....
Human   226 ------SEACAEEEEGLMPQGPQL----------LDFSVDEVAEQLTLIDLELFSKVRLYECLGS 274

  Fly   194 AWTKKDK---HVNTPNIVAFTKRFNHTSFWTVQEILNAE--QPKQRAEIITHFIKVAKKLHELNN 253
            .|:::|:   ...:|.:.|...:||..:...:..:|.|.  ...|||:.:..:|::|::..||.|
Human   275 VWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRN 339

  Fly   254 LHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYL---ESLR---- 311
            ..||.||:||:||..||||.::|..:|::..:.|.:||.||||::|..:.|..|   |:..    
Human   340 FSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQE 404

  Fly   312 -------LPC------IPYLGLFLTDLIYIDLAHPH--KGGLEPEQRRNKMNNILRVISNYQQSN 361
                   ||.      :||||.|||||:.:|.|.|.  :|.|...::|.|...||..|...|:  
Human   405 EDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQR-- 467

  Fly   362 YKHLQKHEATQKYLTS-----IRYIEELQNIFEEDQYKRSLNLEPASPSGPSS------------ 409
                    ..|.|..|     :..:.....:.||..|:.|..:||.:.|.|||            
Human   468 --------RCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKR 524

  Fly   410 -SSCSSKESFNVEVVTPA-----LGCLNLSPAKTIGSMRMASGTKFVPGHRKCRSLGTKFRSSSL 468
             |:..::|..:....:|.     ...|.:||:.:.||...:..::..|......|.|.:..|:.|
Human   525 LSAKLAREKSSSPSGSPGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKL 589

  Fly   469 P 469
            |
Human   590 P 590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RalGPSNP_725613.1 RasGEF 169..335 CDD:459872 62/192 (32%)
PH_RalGPS1_2 578..692 CDD:270120
RGL3NP_001155088.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..54
REM 74..196 CDD:100121 13/78 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..234 12/62 (19%)
RasGEF 243..505 CDD:214539 80/281 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..419 3/21 (14%)
Interaction with HRAS, MRAS and RIT1. /evidence=ECO:0000250 618..713
RA_RGL3 618..704 CDD:340732
Blue background indicates that the domain is not in the aligned region.

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