DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5522 and rasgrf1

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_009291904.1	Gene:	rasgrf1 / 568885	ZFINID:	ZDB-GENE-090311-28	Length:	1263	Species:	Danio rerio

Alignment Length:	390	Identity:	107/390 - (27%)
Similarity:	179/390 - (45%)	Gaps:	43/390 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PTTDYNGYTGQAYAATQFKQSSPPPPPSQQQQQPTRVSKQRSPN--TNGSAHTMACLRQE-KTYK 86
            ||.:  .|...:.|:|.|       |..|:......|.::.:.|  .|...|.::...|: :|..
Zfish   908 PTKE--KYRRMSLASTGF-------PTDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNT 963

  Fly    87 EQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPG----CYYTIAASAAPPSKSQSLP 147
            |.:|:..|...:......:.:..||.:...:.:.:.  :.||    |...: ...|...||:|..
Zfish   964 ELKMKVISFLEEVMHDPELLTQERKAAANIIRTLTQ--EDPGDNQICLEEV-LQMAEGGKSESFE 1025

  Fly   148 AHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTK 212
            .|::::                :|.|:||||..||..|..:|.....|.|.||:..||.|:..||
Zfish  1026 NHSALE----------------IAEQLTLLDHLVFKVIPYEEFFGQGWMKNDKNEKTPYIMKTTK 1074

  Fly   213 RFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWA 277
            .||..|.....|||..|....|..::..::.||.....|:|.:::..|.|::..:||:||.|||.
Zfish  1075 HFNDISDLIATEILRCEDVNVRVAVMEKWVAVADICRCLHNYNAVLEITSSLNRSSIFRLKKTWL 1139

  Fly   278 CLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPH--KGGLEP 340
            .:||:.:...|:|..:.|.:..:.|||..|::...||:||||::||||.:|:...|:  :..|..
Zfish  1140 KVSKQTKTVIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDNLVN 1204

  Fly   341 EQRRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPS 405
            ..:...:::|:|.|..:||:.|| :........||.....:.|     ||..|:.||.:||..|:
Zfish  1205 FSKMRMISHIIREIRQFQQTAYK-IDYQPKAALYLLDRSAVME-----EEGLYEASLRIEPKVPN 1263

Fly 406 405
Zfish 1264 1263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	77/238 (32%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
rasgrf1	XP_009291904.1	PH_RasGRF1_2	19..154	CDD:270081
		PH	24..129	CDD:278594
		RhoGEF	244..425	CDD:214619
		PH-like	474..596	CDD:302622
		PH	489..592	CDD:278594
		RasGEF_N	643..>691	CDD:279012
		REM	<928..997	CDD:295342	11/68 (16%)
		RasGEF	1024..1261	CDD:214539	80/258 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810