DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and rasgrf2a

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_009303357.1	Gene:	rasgrf2a / 558859	ZFINID:	ZDB-GENE-111128-1	Length:	1274	Species:	Danio rerio

Alignment Length:	432	Identity:	118/432 - (27%)
Similarity:	177/432 - (40%)	Gaps:	94/432 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SRKPTTD----YNGYTGQ---------------AYAATQFKQSSPP----PPPSQQQQQPTR--- 60
            ||.|:|.    |....||               |.|......|||.    |..|..::...|
Zfish   885 SRSPSTPRHLRYRQPAGQCPDNSRCAVSPASAFAIATAAAGHSSPQGFTNPEKSYDKEFLIRRAA 949

  Fly    61 -----------VSKQRSP---NTNGSAHTMACLRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRK 111
                       |||....   |...:...||.|       |:.:..|.:.||          .||
Zfish   950 TNRVLNVLRHWVSKHSQDFEMNAELTTAVMALL-------EEVLRDPDLLPQ----------ERK 997

  Fly   112 NSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQLDA------VILSALRVPADVL 170
            .::..|::.|.....                ...|.....::.:|.      ..|||:.     |
Zfish   998 AAVNILSALSQEEQD----------------DSQLKIEDIVQMVDCPRAECFESLSAME-----L 1041

  Fly   171 ANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRA 235
            |.||||||..||..|..:|.....|.|.||:..||.|:..::.||..|.....||:.......||
Zfish  1042 AEQITLLDHIVFRNIPYEEFLGQGWMKMDKNERTPYIMKTSQHFNDMSNLVASEIMAHADVSSRA 1106

  Fly   236 EIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNW 300
            ..|..::.||.....|||.:.:..|.||:..::||||.||||.:.|:.:...|||..|.|.:..:
Zfish  1107 GSIDKWLAVADICRCLNNYNGVLEITSALNRSAIYRLKKTWAKVCKQTKALMDRLQKIVSSEGRF 1171

  Fly   301 ANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPH--KGGLEPEQRRNKMNNILRVISNYQQSNYK 363
            .|||..|::...||:||||::||||.:|:...|:  :.||....:...:::|:|.|..:||:.|:
Zfish  1172 KNLRETLKNCNPPCVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQAPYR 1236

  Fly   364 HLQKHEATQKYLTSIRYIEELQNIFEEDQ-YKRSLNLEPASP 404
            ...:.:.||       ::.:...:.:||. |:.||.:||..|
Zfish  1237 IELQPKVTQ-------FLLDKTLVMDEDTLYELSLKIEPRLP 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	80/239 (33%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
rasgrf2a	XP_009303357.1	PH_RasGRF1_2	19..155	CDD:270081
		PH	24..130	CDD:278594
		RhoGEF	244..425	CDD:279015
		PH	478..585	CDD:214574
		PH	489..584	CDD:278594
		RasGEF_N	635..>683	CDD:279012
		REM	<935..1007	CDD:295342	17/88 (19%)
		RasGEF	1033..1265	CDD:238087	82/243 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810