DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5522 and rasgrf2b

DIOPT Version :9

Sequence 1:NP_725613.1 Gene:CG5522 / 36881 FlyBaseID:FBgn0034158 Length:702 Species:Drosophila melanogaster
Sequence 2:XP_009300046.1 Gene:rasgrf2b / 553520 ZFINID:ZDB-GENE-060504-1 Length:1275 Species:Danio rerio


Alignment Length:515 Identity:130/515 - (25%)
Similarity:197/515 - (38%) Gaps:145/515 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 DLST--DNLRYSELSRKPTTDYNGYTGQAYAATQFKQSSPPP--------PPSQQQQQPTRVSKQ 64
            ||||  .:...|..|..||.                  ||||        ||....:..:..|.:
Zfish   787 DLSTTSSSAASSPTSANPTI------------------SPPPSNNNNNSKPPLDLSRGQSPSSPE 833

  Fly    65 RSP-----NTNGSAHTMACLRQEKTYKEQQMEPPSM------QPQASKTLNIKSTR--------- 109
            :||     |.........|.:..::.:...:|..|:      .||||:...|...|         
Zfish   834 QSPGALDDNAEVPRIDALCGKLRRSIRRAVLESVSLDKFIPESPQASEPGEISPCRSPSTPRHLR 898

  Fly   110 -RKNSIGCLNSFSSSPDSPGCYYTIAASAA----PP----------------------------- 140
             |::.:....: |....||...:.||.:||    ||                             
Zfish   899 YRQSGVQTAEN-SRCSVSPASAFAIATAAAGHSSPPVFNNSERTCDKEFIIRRAATNRVLNVLRH 962

  Fly   141 --SK-SQSLPAHASIK---------------------QLDAVILSAL------------------ 163
              || ||....:..:|                     :..|.|||||                  
Zfish   963 WVSKHSQDFEMNGELKMGVICLLEEVLRDPDLLPQERKATANILSALSQDDQDDAQLKIEDILQM 1027

  Fly   164 ----------RVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTS 218
                      .:.|..:|.||||||..||..|..:|.....|.|.||...||.|:..::.||..|
Zfish  1028 AECPKAECFESLSAMEIAEQITLLDHIVFRSIPYEEFLGQGWMKTDKTERTPYIMKTSQHFNDMS 1092

  Fly   219 FWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKD 283
            .....:|::......||..|..::.||.....|||.:.:..|.||:..::||||.||||.:.|:.
Zfish  1093 NLVASQIMSHTDVGSRAGSIEKWVAVADICRCLNNYNGVLEITSALNRSAIYRLKKTWAKVCKQT 1157

  Fly   284 RNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPH--KGGLEPEQRRNK 346
            :...|:|....|.:..:.|||..|::...||:||||::||||.:|:...|:  :.||....:...
Zfish  1158 KALMDKLQKTVSSEGRFKNLRETLKNCNPPCVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRM 1222

  Fly   347 MNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQ-YKRSLNLEPASPS 405
            :::|:|.|..:||:.|:...:.:.||       |:.:...|.:||. |..||.:||..|:
Zfish  1223 ISHIIREIRQFQQTPYRIEHQPKVTQ-------YLLDKTLIMDEDTLYDLSLKIEPRLPA 1275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5522NP_725613.1 RasGEF 163..400 CDD:214539 80/267 (30%)
PH_RalGPS1_2 578..692 CDD:270120
PH 578..685 CDD:278594
rasgrf2bXP_009300046.1 PH_RasGRF1_2 19..154 CDD:270081
PH 24..129 CDD:278594
RhoGEF 243..424 CDD:279015
PH 476..584 CDD:214574
PH 476..583 CDD:278594
RasGEF_N 634..>682 CDD:279012
REM <938..1010 CDD:295342 10/71 (14%)
RasGEF 1036..1272 CDD:214539 80/242 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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