DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and rapgef1b

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_021324455.1	Gene:	rapgef1b / 394101	ZFINID:	ZDB-GENE-040426-1001	Length:	1204	Species:	Danio rerio

Alignment Length:	258	Identity:	77/258 - (29%)
Similarity:	131/258 - (50%)	Gaps:	26/258 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 LSALRVPA----------DVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRF 214
            |:||.|.|          ..:|:|:||||..:|.:|:..|:  ..|.|:.....:||:..||:.|
Zfish   951 LAALGVSARPGTLHDFRSHEIADQLTLLDAELFYKIEIPEV--LLWAKEQNEEKSPNLTQFTEHF 1013

  Fly   215 NHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACL 279
            |:.|:|....|:..|:.:.|.:::..|||:.|.|.:|||.:|..||:||:.||.|.||  .|
Zfish  1014 NNMSYWVRSIIIQQEKAQDREKLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EW--- 1073

  Fly   280 SKKDRNAFDRLSDIFSDQDNWANLRSYLESLRLPCIPYLGLFLTDLIYIDLAHPH--KGGLEPEQ 342
            .|:.....:....:.....::...|:.|..:..||||||||.|.||.::.|.:|.  :|.:...:
Zfish  1074 QKQTSEGLEEYCTLIDSSSSFRAYRAALAEVEPPCIPYLGLILQDLTFVHLGNPDFIEGKVNFSK 1138

  Fly   343 RRNKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPS 405
            |..:. |||..:..:||.:| .|::::....:.....     .::.||..::.||.::|.:.|
Zfish  1139 RWQQF-NILDSMRRFQQVHY-DLKRNDDIVSFFNDFS-----DHLAEEALWELSLKIKPRNIS 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	73/248 (29%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
rapgef1b	XP_021324455.1	Atrophin-1	<287..538	CDD:331285
		RasGEFN	815..953	CDD:214571	1/1 (100%)
		RasGEF	963..1192	CDD:214539	71/242 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810