DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and ralgps2

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_956768.1	Gene:	ralgps2 / 393446	ZFINID:	ZDB-GENE-040426-1212	Length:	510	Species:	Danio rerio

Alignment Length:	600	Identity:	211/600 - (35%)
Similarity:	297/600 - (49%)	Gaps:	170/600 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 MEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQ 154
            |:.|:.||..| ||...::.|.:|                           |:|.|....:.:|.
Zfish     1 MDVPNGQPSVS-TLTAPASERSSS---------------------------SESLSEKGTSELKS 37

  Fly   155 LDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSF 219
            .|||:...|:|..:..|.||||:|.|||..|||:|||||.|.||:||.:.||.||||:|||..||
Zfish    38 FDAVVFDVLKVTPEEYAGQITLMDAPVFRAIQPEELSSCGWNKKEKHSSAPNAVAFTRRFNQVSF 102

  Fly   220 WTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDR 284
            |.|:|||:|:..|.|||:::.:|:.||||.::|:||::.|::||:|||.|:|||||||.||:||:
Zfish   103 WVVREILHAQTLKIRAEVLSLYIRTAKKLCDMNSLHAVMAVVSALQSAPIFRLTKTWALLSRKDK 167

  Fly   285 NAFDRLSDIFSDQDNWANLRSYLESLRL-PCIPYLGLFLTDLIYIDLAHPHKGG-LEPEQRRNKM 347
            ..|:||..:.|.:||:..||.|:.|..: .||||||::|:||.|||.|:|..|. ||.|||.|.|
Zfish   168 ATFERLEYLMSKEDNYKRLRDYISSQSMTSCIPYLGIYLSDLTYIDSAYPSTGSILENEQRSNLM 232

  Fly   348 NNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSGPSSSSC 412
            |||||:||:.|:|....:......||||.|:|||||||...|:|.||.||.:||.:.|.|.::
Zfish   233 NNILRIISDLQRSCEYEIPVLPHVQKYLNSVRYIEELQKFVEDDNYKLSLKIEPPATSTPRTT-- 295

  Fly   413 SSKESFNVEVVTPALGCLNLSPAKTIGSMRMASGTKFVP-----------GHRKCRSLG------ 460
            :|:|    ::..|.:....|...:  |::...:..|..|           |||||.|||
Zfish   296 ASRE----DLTGPDISASPLCGRR--GNVAEGALPKVPPTPPSPRNLITYGHRKCHSLGYNFIHK 354

  Fly   461 ---TKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFGKIATHNHSDGHPHHLHLELD 522
               .:|:|::.|                      |...|
Zfish   355 TNTVEFKSATFP----------------------NAGSR-------------------------- 371

  Fly   523 PSQVQPRHHLLDDSVLE-------HSDALSQADLTSLESAEG----------------------- 557
                    |||||||||       |:::.:.:...||.|:||
Zfish   372 --------HLLDDSVLESHTPTRGHAESSTLSSGISLGSSEGSELSEEMSWPAFERTRFYHSLGP 428

  Fly   558 ------IMCDFTGSDCDLMSPEAAA-----AMH---------GCVRRKTVQKEGRKPAVASWQRY 602
                  :.|  .||    :.|.::|     |:|         |.:|||||.|||:||.||:|.:|
Zfish   429 VTRVGRMSC--RGS----LRPSSSAESEELAVHLYPGAVTVQGVLRRKTVLKEGKKPTVAAWTKY 487

  Fly   603 WLQIWANSLVYFPPK 617
            |:.:....|.|:..|
Zfish   488 WVALCGTQLYYYTAK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	130/238 (55%)
		PH_RalGPS1_2	578..692	CDD:270120	19/48 (40%)
		PH	578..685	CDD:278594	19/48 (40%)
ralgps2	NP_956768.1	RasGEF	45..287	CDD:214539	131/241 (54%)
ralgps2	NP_956768.1	PH-like	462..>504	CDD:302622	18/40 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2835
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2121
OMA	1	1.010	-	-		QHG49702
OrthoDB	1	1.010	-	-		D184404at33208
OrthoFinder	1	1.000	-	-		FOG0003356
OrthoInspector	1	1.000	-	-		otm24885
orthoMCL	1	0.900	-	-		OOG6_104897
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5234
SonicParanoid	1	1.000	-	-		X2715
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010