Protein Alignment CG5522 and Rasgrp2

DIOPT Version :9

• Sequence 1: NP_725613.1
• Gene: CG5522 / 36881
• FlyBaseID: FBgn0034158
• Length: 702
• Species: Drosophila melanogaster
• Sequence 2: NP_001076446.2
• Gene: Rasgrp2 / 361714
• RGDID: 1311630
• Length: 608
• Species: Rattus norvegicus
• Alignment Length: 562
• Identity: 129/562 - (22%)
• Similarity: 209/562 - (37%)
• Gaps: 167/562 - (29%)

  Fly    90 MEP---PSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHA- 150
            |.|   ||.| .|||.|:.....||::       |:|.....|:......:|.|::....|..|
  Rat    42 MHPWYIPSSQ-LASKLLHFYQQSRKDN-------SNSLQVKTCHLVRYWVSAFPAEFDLNPELAE 98

  Fly   151 SIKQLDAV-----------ILSALRVPADVLANQITLLDFPV----------FAQIQPDEL---- 190
            .||:|.|:           ::....||......|:|..: ||          |..::|.||
  Rat    99 QIKELKALLDQEGNRRHSSLIDIESVPTYKWKRQVTQRN-PVEQKKRKMSLLFDHLEPMELAEHL 162

  Fly   191 ------SSCAWTKKDKH--------VNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHF 241
                  |.|....:|.|        |:.|.:..|...||..|.|....||:.....|||.:||||
  Rat   163 TYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTATQRALVITHF 227

  Fly   242 IKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSY 306
            :.||:||.:|.|.::|.|::..:..:||.||.:|.:.:|......::.|:::.:...|::|.|..
  Rat   228 VHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGLTELVTATGNYSNYRRR 292

  Fly   307 LESLRLPCI----PYLGLFLTDLIYIDLAHPHKGGLEPEQRR---NKMNNILRVISNYQQSNYKH 364
            |.:    |:    |.||:.|.||:.:.||.|  ..|:|.:.|   .||..:..::.  :.:....
  Rat   293 LAA----CVGFRFPILGVHLKDLVALQLALP--DWLDPGRTRLNGAKMRQLFSILE--ELAMVTS 349

  Fly   365 LQKHEATQKYLTSIRYIEELQNIFEEDQYKRSLNLEPASPSGPSS-SSCS--------------- 413
            |:........|.|:..:...|...|::.|:.||..||.|.|.|:| :||:
  Rat   350 LRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSVA 414

  Fly   414 --------------------------------SKESFNV------------EVVTPALGCLN--- 431
                                            |:|.|.:            ::.....||::
  Rat   415 KPKLDQALVAEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREE 479

  Fly   432 -----LSPAKTIGSMRMASGTKFVPGH-------RKCRSLGTKFRSSSLPRNFAEKCQCCIVMIA 484
                 |..:..:|. ||.....|...:       |.|::|........|      ||:.|
  Rat   480 MISYFLRSSSVLGG-RMGFVHNFQESNSLRPVACRHCKALILGIYKQGL------KCRAC----- 532

  Fly   485 PGIGTISNKRCR------CRRIFGKIATH----NHSDGHPHH 516
               |...:|:|:      |||....::..    :.|..|.||
  Rat   533 ---GVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSPTHTHH 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	72/271 (27%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Rasgrp2	NP_001076446.2	RasGEFN	7..121	CDD:214571	22/86 (26%)
		RasGEF	150..387	CDD:214539	67/244 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..405		9/22 (41%)
		EFh	430..481	CDD:238008	5/50 (10%)
		C1_RASGRP2	496..551	CDD:410411	13/68 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..596		4/17 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810