DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5522 and Sos

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	480	Identity:	120/480 - (25%)
Similarity:	207/480 - (43%)	Gaps:	93/480 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SMQPQASKTLNI---KSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAAPPSKSQSLPAHASIKQL 155
            ||:......|.|   |:.:.|::...:.::...|              ||     :..|.|:..
  Fly   776 SMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDP--------------PP-----IEHHLSVPN- 820

  Fly   156 DAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTPNIVAFTKRFNHTSFW 220
            |.:.|..|. |.: ||.|:|||:|.::..::|.||....||||||.|.:||::...|...:.:.|
  Fly   821 DEITLLTLH-PLE-LARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRW 883

  Fly   221 TVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRN 285
            ..:.|..||..::|..|:...|:|...:.||||.:.:.:|::||.:||:|||..|:..|.::.|.
  Fly   884 IEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRK 948

  Fly   286 AFDRLSDIFSDQDNWANLRSYLESLRL---PCIPYLGLFLTDLIYIDLAHPH---KGGLEPEQRR 344
            ..:...::..|     :|:.|.|.||.   ||:|:.|.:||::::::..:|.   ...|....:|
  Fly   949 FLEECRELSDD-----HLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSKR 1008

  Fly   345 NKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQ--NIFEEDQ-----YKRSLNLEPA 402
            .|:..|:..|..||  |..:....|:|.:     ::.|:|.  |...:.|     |..||.:||
  Fly  1009 RKVAEIIGEIQQYQ--NQPYCLNEESTIR-----QFFEQLDPFNGLSDKQMSDYLYNESLRIEP- 1065

  Fly   403 SPSGPSSSSCSSKESF-----NVEVVTPALGCLNLSPAK---TIGSMRMASGTKFVPGHRKCRSL 459
                   ..|.:...|     ::.:.:|     .:.|.:   |..|.::::.|..|.......|.
  Fly  1066 -------RGCKTVPKFPRKWPHIPLKSP-----GIKPRRQNQTNSSSKLSNSTSSVAAAAAASST 1118

  Fly   460 GTKFRSSSLPRNFAEKCQCCIVMIAP-------GIGTISNKRC-----RCRRIFGK--IATHNHS 510
            .|...::|.|...|..     :|.||       |.||::.::.     ....:|..  |...|.|
  Fly  1119 ATSIATASAPSLHASS-----IMDAPTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTS 1178

  Fly   511 --DGHPHHLHLELDPSQVQ-PRHHL 532
              .|.|.|...:.:..:|. |..||
  Fly  1179 SWSGTPQHTRTDQNNGEVSVPAPHL 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	75/249 (30%)
		PH_RalGPS1_2	578..692	CDD:270120
		PH	578..685	CDD:278594
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	4/14 (29%)
		RasGEF	825..1062	CDD:238087	75/250 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840