DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5522 and rapgef6

DIOPT Version :9

Sequence 1:	NP_725613.1	Gene:	CG5522 / 36881	FlyBaseID:	FBgn0034158	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	XP_017208494.2	Gene:	rapgef6 / 335032	ZFINID:	ZDB-GENE-030131-6972	Length:	1546	Species:	Danio rerio

Alignment Length:	867	Identity:	177/867 - (20%)
Similarity:	277/867 - (31%)	Gaps:	261/867 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DNLRYSELSRKPTTDYNGYTGQAYAATQFKQ-----SSPPPPPSQQQQQPTRVSKQRSPNTNGSA 73
            :..|:|.|..||.:|......|..:....||     :..|.|.|....         ||:....|
Zfish   691 EKTRFSILPPKPFSDSGVCQSQDDSIVGTKQCRHSVAIMPIPGSLSSS---------SPDLLQPA 746

  Fly    74 HTMACLRQEKTYKEQQMEPPSMQPQASKTLNIKSTRRKNSIGCLNSFSSSPDSPGCYYTIAASAA 138
            .|:..........:|.:.......|::..:..|.|..|:.:..:.|......:...|.....|.:
Zfish   747 ATVLDFSNPSDIPDQVIRVFKADQQSAYIIISKDTTAKDVVSHVVSEFGLIAAAETYSLCEVSVS 811

  Fly   139 PPS--KSQSLPAHASIKQLDAVIL------------------------------SALRVPADVLA 171
            |..  |.:.||...| |..|.:.|                              |.|::....:|
Zfish   812 PEGVIKQRRLPDQLS-KLADRIQLNGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTVEVA 875

  Fly   172 NQITLLDFPVFAQIQPDELSSCAWTKKDKHVNTP-------NIVAFTKRFNHTSFWTVQEILNAE 229
            .|:::.||.:|..|:..|...      |.....|       ::..|.:..|..:||...|||...
Zfish   876 AQLSMRDFSLFRNIESTEYVD------DLFKLDPGGGGGAGHLKQFEEIINQETFWVSTEILREP 934

  Fly   230 QPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIF 294
            ...:|.:.|.||||:|....|..|.:|:|||||.:..|.:.||..||..|..|....|..|.|||
Zfish   935 NAIKRMKTIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRSTWEKLPSKYEKLFRDLQDIF 999

  Fly   295 SDQDNWANLRSYL--ESLRLPCIPYLGLFLTDLIYIDLAHPHKG--------------------- 336
            ....|.|..|:.|  :|::.|.||...:...||.::     |:|
Zfish  1000 DPSRNMAKYRNILSSQSVQPPIIPLFPVVKKDLTFL-----HEGNDSSVDGLVNFEKLRMIAKEI 1059

  Fly   337 ---------GLEP----EQRRNKM------------NNILRVISNYQQS-------NYKHLQKHE 369
                     .::|    .||:.:.            :|:|.|..|:::.       |.|.|  :|
Zfish  1060 RHVVRMTSANMDPALMFRQRKKRWKSLGSLSQGSTNSNLLDVQGNHKKRVRRSSLLNAKKL--YE 1122

  Fly   370 ATQKYLTSIRYIEELQNIFEEDQYK-RSLNLEPA------------------SP----SGPSSSS 411
            ..|......:|:..|:...:|:::: .||..|.|                  ||    ||.|||.
Zfish  1123 DAQMARKVKQYLAHLEVETDEEKFQIMSLQCEAAYSTLSKNLSERRSTKSDMSPVSLRSGLSSSR 1187

  Fly   412 CSSKESFNVEVVTPALGCL-----------NLSP----------------------AKTIGSMRM 443
            ..::.|..::|...:|..|           ..||                      ..|:.|:..
Zfish  1188 TQNRVSQVLQVPPVSLYPLRKKSIAKDLAATFSPNSPQTLKKSAGAAEDSRRTEESLSTVSSLHS 1252

  Fly   444 ASGTKFVPGHRKCRSLGTKFRSSSLPRNFAEKCQCCIVMIAPGIGTISNKRCRCRRIFG---KIA 505
            :.........||.....::...||.|              |||           .|.:|   .:.
Zfish  1253 SPTVSPQGSPRKVSVSSSRQNGSSAP--------------APG-----------GRTYGIGYALM 1292

  Fly   506 THNHSDGHPHHLHLELDPSQVQPRHHLLD----DSVLEHSDALSQADLTSLESAEGIMCDFTGSD 566
            ....||        ..|.|::..|..::.    ||.|..:.|...|:..:|        ..|.:|
Zfish  1293 PAGRSD--------LSDSSEISSRSSIVSNCSVDSGLTAAPASVPAETHTL--------THTPAD 1341

  Fly   567 CDLM-----SPEAAAAMHGCVRRKTVQKEGRKPAVA-SWQRYWLQIWANSLVYFPPKSFKGSERN 625
            |...     |..|.:.:.......|..:......:| |.:..|....:||     ..|.:..:|
Zfish  1342 CSWSSSVRDSTVALSTVSNSAEELTAPEHSSVSEIADSGRASWTSCSSNS-----QDSLQTVQR- 1400

  Fly   626 DFKREPCKV--CPLDGWYAHVS-------------DNTKHKNTFELCHRTLGTVYRFRTDSPQ-- 673
              ..||..:  .|:.|..|.|.             |..||.:|    ....|:.|:..|.|.:
Zfish  1401 --APEPLSLRHTPMGGPIAEVDPALLEERDSEDGYDPVKHNST----DPADGSDYKTITSSTEKG 1459

  Fly   674 MTHLWSNAICKLATMRVPKPLP 695
            :......:.||....|.|.|.|
Zfish  1460 LIVYCVTSPCKDERFRAPPPTP 1481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5522	NP_725613.1	RasGEF	163..400	CDD:214539	73/299 (24%)
		PH_RalGPS1_2	578..692	CDD:270120	25/131 (19%)
		PH	578..685	CDD:278594	23/124 (19%)
rapgef6	XP_017208494.2	CAP_ED	49..154	CDD:320730
		cNMP	290..405	CDD:197516
		RasGEFN	421..534	CDD:214571
		PDZ_signaling	538..618	CDD:238492
		UBQ	759..843	CDD:320785	16/84 (19%)
		RasGEF	866..1102	CDD:214539	61/246 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000